ID   A0A087X9I2_POEFO        Unreviewed;       339 AA.
AC   A0A087X9I2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=THAP-type domain-containing protein {ECO:0000259|PROSITE:PS50950};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000002435.1, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000002435.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC   -!- SIMILARITY: Belongs to the E2F/DP family.
CC       {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR   EMBL; AYCK01019334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A087X9I2; -.
DR   STRING; 48698.ENSPFOP00000002435; -.
DR   Ensembl; ENSPFOT00000002439.1; ENSPFOP00000002435.1; ENSPFOG00000002604.1.
DR   eggNOG; KOG2577; Eukaryota.
DR   GeneTree; ENSGT00940000155734; -.
DR   OMA; TLIKSCA; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd14660; E2F_DD; 1.
DR   Gene3D; 6.10.250.540; -; 1.
DR   Gene3D; 6.20.210.20; THAP domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR015633; E2F.
DR   InterPro; IPR037241; E2F-DP_heterodim.
DR   InterPro; IPR032198; E2F_CC-MB.
DR   InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR   InterPro; IPR006612; THAP_Znf.
DR   InterPro; IPR038441; THAP_Znf_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR   PANTHER; PTHR12081:SF19; TRANSCRIPTION FACTOR E2F6; 1.
DR   Pfam; PF16421; E2F_CC-MB; 1.
DR   Pfam; PF02319; E2F_TDP; 1.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM01372; E2F_TDP; 1.
DR   SMART; SM00980; THAP; 1.
DR   SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00309}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00309};
KW   Nucleus {ECO:0000256|RuleBase:RU003796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU003796};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU003796};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00309};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00309}.
FT   DOMAIN          1..82
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50950"
FT   REGION          97..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   339 AA;  37680 MW;  80DCE537CA8A2694 CRC64;
     MVKCVVSGCP NRVDGSNHGV FDGTQKQFFT FPQDPTRVKV WLAALRQADQ QNQNQNLICE
     DHFLPEDILS GDVSADAIPI MPPCLDGPLD PLDRWGAGSE DDEDQWVGTA GPGEEEEDEA
     CLPFNTKMAA PELPALDPTE QNPALKAVPE GPILSQQQQN GPIRTQTRED VSLLVLTRRF
     LDLFLTAPDG CLDLRSAIAS LRTRRRRVYD ITNVLQGVQL VQKESVNRIR WIGSSPASSY
     LGQNRAQSNM ADLKLVEETL DSLIRTSAEQ LFHLTDDPYN SRLAYVTRQD LVELQNLQNQ
     TVLVVKAPEE TKLEVPAPSE VSRTTEWVGP GHNQTEVLF
//