ID A0A087XAF7_POEFO Unreviewed; 503 AA.
AC A0A087XAF7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 26 {ECO:0000256|ARBA:ARBA00019686};
DE AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 7 {ECO:0000256|ARBA:ARBA00030125};
DE AltName: Full=Mediator complex subunit 26 {ECO:0000256|ARBA:ARBA00031968};
GN Name=MED26 {ECO:0000313|Ensembl:ENSPFOP00000002760.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000002760.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000002760.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 26 family.
CC {ECO:0000256|ARBA:ARBA00009681}.
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DR EMBL; AYCK01008317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007560620.1; XM_007560558.2.
DR AlphaFoldDB; A0A087XAF7; -.
DR STRING; 48698.ENSPFOP00000002760; -.
DR Ensembl; ENSPFOT00000002764.1; ENSPFOP00000002760.1; ENSPFOG00000002885.1.
DR GeneID; 103143853; -.
DR KEGG; pfor:103143853; -.
DR CTD; 9441; -.
DR eggNOG; KOG1105; Eukaryota.
DR GeneTree; ENSGT00390000000259; -.
DR OMA; WTECISV; -.
DR OrthoDB; 4048705at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00183; TFIIS_I; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR042376; MED26.
DR InterPro; IPR031416; Med26_C.
DR InterPro; IPR031417; Med26_Mid.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15201; CRSP70; 1.
DR PANTHER; PTHR15201:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26; 1.
DR Pfam; PF08711; Med26; 1.
DR Pfam; PF15693; Med26_C; 1.
DR Pfam; PF15694; Med26_M; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 10..87
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 88..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 56278 MW; E1F1F9B1C04E7E83 CRC64;
MSAATATARV MRDRLLQAID GQNNIRNMMV VVEVISSLEK CSITKEVLEE TRLGKLVNDI
RKKTKNEDLA KRAKKLLRTW QKLIDPGQGD LVPKELTGAS WPSKGSIHSC SSPPALSKTG
SELKARSDFN NYSPNPEPIS NRKRRCDKKE GQTKIPKVAH DDAKQQPSHG LGGSFKIPAN
TNAHQPSDRD TSKYLDNSKS NKVPIHAVKP HPSASNPPNT LMQRQVRRDK HQPRSPGCPL
QHPECLKQEA VLKKPQSSGN PGVMEESAQS FNVHTNLSGF ANLGFQSRTS SLDDETIIND
AVNKKREKYK AKDHVVNLNG PITEDKSKPA RIKDRRITFD PSTGQIKFTC PKESSEEQEV
SELLLKLSQP IPPSPFQQTD WKELSRSEII QSYLTQQSNI LLSGAHTPGA NLFMSEVCKR
ADHQKRNTTE TSILVSDHHV KELPGVGREI SSEDLNRLQR RRWSGVNGCY DTKGNWYDWT
ECISVDPHGD ESRLNILPYV CLD
//
