ID A0A087XAP9_POEFO Unreviewed; 895 AA.
AC A0A087XAP9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=DNA cross-link repair 1A {ECO:0000313|Ensembl:ENSPFOP00000002852.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000002852.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000002852.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01015876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XAP9; -.
DR STRING; 48698.ENSPFOP00000002852; -.
DR Ensembl; ENSPFOT00000002856.1; ENSPFOP00000002852.1; ENSPFOG00000002895.1.
DR eggNOG; KOG1361; Eukaryota.
DR GeneTree; ENSGT00940000158766; -.
DR OMA; WSSRKAM; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 138..160
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 21..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 99357 MW; 9C306DE0DEFF0733 CRC64;
MSQKDDSEND IWEYKPLEKK RKSNKSLWIS KRRCTARKTS KKDSSPSLRS KEKSTKPKTS
ESGDSSAVGE AVESKLLLSN ELPVKCSATE VIQSDSNAAE RQMSEDFCPI CQMPFHILVV
QSQRWHVAEC LDNPRDKCTE CPDGLLCSST IPNHYKKFNH TLLAETRANG NAAAPSLSLQ
TETSGEANLQ NIQNNEALSF PLARSQGTTS FPSSFSSLNH TPTPPTKPRN GLLLLRSPGP
DDFKKKKGWL GNNNNNKAQK PVGEISSTPV KEILSDRACE VSTETQTSLK DDDDDDGISY
SPLSELPAET EMNCRKSLFL NESSGNEHSV ILFNDSFSSE DEILAEFIDK NCDEGAAFDD
PSSSSSSQLD PVSSLAPTNQ QAAEIPRVSK REISSFQSPQ SAVLERLRET ICSEGHSSQK
LNSAQVSSSQ DPFGPNYQNM LPQKGQSKAV QGSGLKQTDI GVFFGLKPLK ETDNKSLQSN
LEASSVPASD KNPGRHRQKK RKADPEAAPA AAAAAFGNDS VGAQGDAGRG GNRGWRRRWN
RVNADGEVQL PRCPFYKKIP GTKFVVDAFR YGEIEGITSY FLTHFHSDHY DGLTRTSTFP
IYCNRITGNL VKSKLRVAEQ FVHILPMNAE VTVEGVRVVL LDANHCPGAA MLLFFLPDGQ
TVLHTGDFRA NPSMETYPEL LHCRVQTLYL DTTYCSPEYT FPRQQEVVSF AASRAFELVT
LHPRTLVVCG SYSVGKEKVF LALAEVLGSK VCLSRDKYNT MCCLESQQIK ERITTDWKAA
QVHVLPMMQL SFKKLQDHLA RFSAQYDRLV AFKPTGWTFS EQVESVEDIQ PQISGNISLY
GIPYSEHSSF LELKRFVQWL KPLKIIPTVN VGSWSSRKAM EKCFSEWLSE ARAKL
//
