ID A0A087XBI1_POEFO Unreviewed; 830 AA.
AC A0A087XBI1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Bromodomain-containing protein 2 {ECO:0000256|ARBA:ARBA00040998};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000003134.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000003134.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer. Interacts with E2F1 and with histone H4 acetylated
CC at 'Lys-13'. {ECO:0000256|ARBA:ARBA00038820}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AYCK01010107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007564371.1; XM_007564309.2.
DR AlphaFoldDB; A0A087XBI1; -.
DR STRING; 48698.ENSPFOP00000003134; -.
DR Ensembl; ENSPFOT00000003138.2; ENSPFOP00000003134.2; ENSPFOG00000003172.2.
DR GeneID; 103146400; -.
DR CTD; 30445; -.
DR eggNOG; KOG1474; Eukaryota.
DR GeneTree; ENSGT00940000153385; -.
DR OMA; SDVHAQP; -.
DR OrthoDB; 152619at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030902; P:hindbrain development; IEA:Ensembl.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
DR GO; GO:0002574; P:thrombocyte differentiation; IEA:Ensembl.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF240; BROMODOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 92..164
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 408..480
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 662..744
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..587
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 91676 MW; D167A03ECC03463B CRC64;
MDMAVNPPLD STHSGVDPGF TGVTMDQSTG TAGKRIRKPS QLYEGFESPG MPPISQLTPL
GPPQPTVKDP SRQGRMTNQL QFLQKVVLKS LWRHHFAWPF HEPVDAIKLG LPDYHKIIKN
PMDMGSIKKR LENNYYRSAS ECMQDFNTMF TNCYIYNKPT DDIVLMAQSL EKAFLQKVAQ
MPQEEIELAP PPPRSKSAKS SKKARNNPVP GGVTTAHQVP AVSQSAYSPP TPETPDSILS
TPPQTILSKS ITFPSEHSIP SITSMPPTQP TAKKKGVKRK ADTTTPTTMA MPIMSTMGVS
GIGLGMGGGL DSPLTLTSLG MEHSGGLGMT PGLGLGQGMV MSMEMAHGGM MMGNKGTAAS
RRGVSGRPIK PPKKDLPDSI LPTPVRRSKL TPQLRYCSNV LKELLSKKHA AYAWPFYKPV
DAMSLGLHDY HDIIKQPMDL STIKRKMDSR EYRDSQQFSA DVRLMFSNCY KYNPPDHDVV
AMARKLQDVF EFCFAKMPDE PPAPPTSSSS STSCSSSSSE SEFSSDSEES DSSLSSDSEE
ERANRLAELQ EQLKAVHEQL TALSQGPIVK PKKKKEKKDK KKKKKVEKHR RMDEEIVSVK
PPKTPKMSKS SKTTKSNKGI SCPVMPVKKT QSKKTNKSKS KKTNMMFSVS QPMHDPLVSH
FDSDEEEDTV PMSYDEKRQL SLDINKLPGE KLGRVVYIIQ SREPSLRDTN PEEIEIDFET
LKPSTLRELE RYVMTCLRKK PRKPYASKKN SAGKTREELA MEKQMELERR LMDVSGQLNS
GKKPSKTKND KPASDVHAQP SRLSASSSSS DSSSSSSSSS SSDTSESDSG
//
