ID A0A087XCC7_POEFO Unreviewed; 896 AA.
AC A0A087XCC7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Interleukin-6 receptor subunit beta {ECO:0000313|Ensembl:ENSPFOP00000003430.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000003430.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000003430.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01015763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007574115.1; XM_007574053.2.
DR AlphaFoldDB; A0A087XCC7; -.
DR STRING; 48698.ENSPFOP00000003430; -.
DR Ensembl; ENSPFOT00000003436.2; ENSPFOP00000003430.2; ENSPFOG00000003395.2.
DR GeneID; 103153225; -.
DR KEGG; pfor:103153225; -.
DR CTD; 3572; -.
DR eggNOG; ENOG502QXEG; Eukaryota.
DR GeneTree; ENSGT00940000155603; -.
DR OMA; RYILEWC; -.
DR OrthoDB; 5354422at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF83; INTERLEUKIN-6 RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 642..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 242..343
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 540..634
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 324..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 100028 MW; 4AB8FAFA93CDE9CC CRC64;
MKLLFSSGAV VMMSSMVLQL FGLAFVASVL HAKHEFSTHL VTSPHVPVVE IGTNFTATCV
IVNTVEVTAD SLYWNLSESS VVPEKNYIKI NESALAVTIL ISGEESEWLF CSCKKNSPYV
SLNKSKFIHG IYLKKAYPPR RVENLSCVAE QDGKLVSGFL NCKWDAVGGQ TEDVKTNYTV
MVQHESGTYR SKTTFLNKTM VDLGFFPHFM HFDVWVVADN LLGTVESEHL KQDANEFVKT
DPPSKVTAFP EELFPNCLLI KWEHPIEDVR IKLTYQIRYC ESGSHTWSYI PLGDTDKVIT
SFRLQNLQPN SAYVIQMRCR NREGNSGPWS NWSANETKTT PEDRPRSKPD LWQLSGGDHG
EEVQIICKDP KHANGRITSF GLILYNKNGP LEQEIIPADQ NQNSSESRVT VLKKISLADK
QFVRVCVNAN NSKGTSPEAC LILVRSSEKT TVEKLKVWTQ EGQMFVEWKR PNNTAVSEYV
VEWARHGKTD WQRENKTTTR TAIKGSLEKF VRYNVSVYVI QSGRVWKLVH KEAYLEQGAP
EQGPTINKSY PAYDNAHLVW DEIPLDKRRG FITNYNISYR KENEAPKSIR VAANNTSYTL
TELLGNTKYE VWISASTVAG SKSSNPHSFT TLRYAPGTIE GIVVGVSLGF LFFVLMALLL
CFLKKDVLKE NFWPQIPNPG ESTIGNWSPD YPPKEETPKE NCVSGVSVLD VGVCEVKLGF
EEDKTSLSLK KGKYLSEEHS SGIGGSSCMS SPRQSVSDSD EGPDLADSTA STVQYSSVVA
SSGYKGQTPS SHSQHSIFSR SESTQPLLDS EEHPDVSLQE GCRQVQPPPR PSLFTGAENQ
NSMESDDFRL LGVEQHDFCP LREDTELTTE PDSLSADTES GAVSSYMPQL GGYRPQ
//
