ID A0A087XDS9_POEFO Unreviewed; 1176 AA.
AC A0A087XDS9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Potassium channel subfamily T member 2-like {ECO:0000313|Ensembl:ENSPFOP00000003932.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000003932.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000003932.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AYCK01014645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XDS9; -.
DR STRING; 48698.ENSPFOP00000003932; -.
DR Ensembl; ENSPFOT00000003940.2; ENSPFOP00000003932.2; ENSPFOG00000002990.2.
DR eggNOG; KOG3193; Eukaryota.
DR GeneTree; ENSGT00940000166551; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF35; POTASSIUM CHANNEL SUBFAMILY T MEMBER 2-LIKE; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1176
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001832738"
FT TRANSMEM 61..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 169..234
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 391..505
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 588..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1150..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1037
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 132609 MW; 071E4FF56937A4DD CRC64;
MFNFALKVLS CLLYIVRVLL DNPQEDRQDC GSGVNCTKQN TSSRPWSEFD WKLIIWVDRP
LPLWALQVLV AFISFSETML LVYLSYKGNV WEQVLRVPFI LEMISTVPFM ITVILPSLRN
IFIPVFLNCW LAKHALENMI NDLHRAIQRT HSAMFNQVVI LISTLVCLMF TCICGIQHLE
RAGNNLTLFD SLYFCVVTFS TVGFGDVTPQ IWPSQLLVVI MIFVALIVLP IQFEQLAFLW
MERQKSGGNY SRYRAQTEKH VVLCVSCLKI DLLMDFLNEF FAHPRLQDYY VVILCPAEMD
VQVRRVLHVP LWALRVIYLQ GSALKDQDLM RAKMDDAEAC FILSNRFEVD RIAADHQTIL
RAWAVKDFAP NCPLYVQILK PENKFHVKFA DHVVCEEEFK YAMLALNCVC PGTSTLITLL
IHSSRGQTTP QEAFKQRAGA FQALNRDGGA GSSDQWHRTY RRCSANEVHH IRLEESKFFG
EYQGKSFTFA SFHAHKKFGV CLIAVRRLDT TNILLNPGPC HIMGASDTCF YINISKEENS
AFVRGQREPS WGGTGGNSRG VHQSIYHGLT RLPVHSIIAS MGTVAIDLQD SSDSSPEGQD
PGGTGLGSGR GSRSSSRVEM GGANTLALPV MGDSGDERRH SIAPVLELVD GVNNPTFDLL
GEQSEDEGGE EGKDDGDKDE SAHWWGRHCE WVKGYPLNSP YIGSSPALCH LLQEKMPFCC
LRMDKPCPHI PFEDARSYGF KNKLIIVSAE SAGNGLYNFI VPLRAYYRTR KELKPIVLLL
ESIPEADFLE AICWFPMVFY TVGSIENLDS LLRCGITFAD TMVVFDKESS MIAEEDYMAD
AKTIVNVQTL FRLFPALSII TELTHPANMR FMQFKVKDHY SLALSKLEKK EREKGSNLVF
MFRLPFAAGK VFSVSMLDTL LYQSFVKDYM ISITRLLLGL DSMPGSGFLC AMKITEDDLW
IRTYGRLYQK LCSSTGDIPI GIYRTEAHKL PVSESQVSIT VEDYEDTREP REPLLSRTGA
HRNSTSSEPV STSSHSSDHP LLRRKSMQWA RRLSRKGGRG SSGAKGGPGS AAERISQQRL
NLFRRSERQE LNSLVRTRMK HLGLSPTGFN GMTDQGNRLS YILINPSPDT RLDLHDVVYL
IRPDPLSLVP NQGSSRKCSA GLSESHRFDM QDSTHL
//
