ID A0A087XDW0_POEFO Unreviewed; 591 AA.
AC A0A087XDW0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Rho GTPase activating protein 25 {ECO:0008006|Google:ProtNLM};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000003963.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000003963.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01010342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XDW0; -.
DR STRING; 48698.ENSPFOP00000003963; -.
DR Ensembl; ENSPFOT00000003971.2; ENSPFOP00000003963.2; ENSPFOG00000004027.2.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00950000183015; -.
DR OMA; MIKQHET; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF20; RHO GTPASE-ACTIVATING PROTEIN 25; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 3..107
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 120..310
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 343..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 523..585
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 380..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 66748 MW; A8876D4D99B14CA4 CRC64;
MEMPLKAGWL KKQQRSLVKN WQQRYFVLRG STLTYHKDDK ETTVQGVIQL RFSKVNELTP
SSDDAGKYLF EITPHSTGDR ERCPYVLMAS SQSDLDDWVR TLRRVIGMPT SAVFGKSLID
TLTYEQRFGP HTVPILVQKC AEFIIEHGLE EEGIFRLPGQ DNAVRQFRDA FDAGERPSFP
SDTDVHTVAS LLKLYLRELP EPVVPWSQYQ DFLDCTNLLD TRSKEGWEKL EQQVALLPRA
NYNILSYVCR FLFQVQQHSD VNKMNVENLA TVMGINLLKP QLEDPMTVMK ATPQIQNLMR
VMIKQHETLF PVSKDVLPAS PSNKADSQKN APRSFVGWES AELGDASMSE SPEEEEDIDS
PGPLRSDFLH KPVVQDPTSP GADDWSSSPR KRTQTLPTFN CPLTGMAAKA DALNRWSRIH
ESGEEKSGTL SEDIFKILDL RTSGSFFGGT QMSVQEDGSR LTERRGSDHT SSSSTTAAQK
PESSLQPARV LTHQKSVDSL MANRAVQQVN SKPNQKEDPE QLAKTIEQQN KELKAAVAEL
QAALEAERRR VAALEICLKN AERSRDQAQK RNDELQRDIQ QFLVREKQAS T
//
