ID A0A087XGN2_POEFO Unreviewed; 562 AA.
AC A0A087XGN2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000004935.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000004935.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; AYCK01008239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01008240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XGN2; -.
DR Ensembl; ENSPFOT00000004944.1; ENSPFOP00000004935.1; ENSPFOG00000004947.2.
DR GeneTree; ENSGT01050000244891; -.
DR OMA; IVPICIR; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF12; IMPORTIN SUBUNIT ALPHA-1; 1.
DR Pfam; PF00514; Arm; 7.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 4.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 27..93
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 153..196
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 196..224
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 285..327
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 327..369
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 562 AA; 61993 MW; C6FA371B2ADB4E0D CRC64;
MHEVLLFKRN NKRHKTVCTG ITPLQDLFSA LPNHTHTHKM SENVARLNKF KNKGRDANEL
RRRRVEVNVE LRKAKKDDQM FKRRNVAAAP DEATSPLQER NQNCQAFRQW TVEEIVAGVN
SGSLESQLQA TQAARKLLSR DKHPPIDQMI ASGLIPKFVS FLALTDCPPI QFEASWALTN
IASGTSAQTM AVVDGGAIPA FISLVTSPQQ HISEQAVWAL GNIAGDGSAL RDRVLKHGAV
APLLTLLAVP DLTVFTPGYL RNVTWTLSNL CRNKNPSPPV HAIQQILPAL VRLLHHDDLE
VLADACWAVS YLTDGSNDRI EMVVETGVIP RLVKLLGFQE LAVVTPALRA LGNIVTGTDE
QTQAVLDASA LSMFPHLLRH KKANIQKEAA WTLSNITAGK DTQIQEVINA GLVPYMVDML
VRGDYKTQKE AVWAVTNFTS GGTVQQVVYL VQANVLEPLL NLLSSKDSKI VLVILDAITN
IFMAGDKIGE SDKLSLMIEE CGGLDKIEAL QAHENESIYK AALNLIEKYF SEEEEEVQCV
IPEATDDGYA FQISENQSTF NF
//
