ID A0A087XND3_POEFO Unreviewed; 2272 AA.
AC A0A087XND3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Myosin XVAa {ECO:0000313|Ensembl:ENSPFOP00000007286.2};
GN Name=MYO15A {ECO:0000313|Ensembl:ENSPFOP00000007286.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000007286.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000007286.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AYCK01010977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01010978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000007286; -.
DR Ensembl; ENSPFOT00000007298.2; ENSPFOP00000007286.2; ENSPFOG00000007263.2.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000155335; -.
DR OMA; YITREST; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13201; FERM_C_MyoXV; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041795; MyoXV_FERM_C.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF21; UNCONVENTIONAL MYOSIN-XV; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..683
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 827..982
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1604..1686
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1785..1942
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1948..2272
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 562..584
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1227..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1320..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1758..1778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1245
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 96..103
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2272 AA; 258700 MW; 3AFFB7FE8D04E8D9 CRC64;
EEDGVEDMTQ LEEMHEGAVL LNLRRRFDRQ LIYTYIGSIL VSVNPYKMYN IYGTDVVLLY
KGRALGEHPP HLFAIANAAY SKMMDAKENQ VIIISGESGS GKTEATKLVL RYLAAIDHNS
NPVQQMMAFH EILEAAPLLE SFGNAKTVRN NNSSRFGKYI EVYLEDGIIS GAITSQYLLE
KSRIVFQAKD ERNYHIFYEM LAGLPSQQKQ AFYLQDAETY YYLNQGGDYL IRGKSDADDF
RRLLSAMEIL HFTPEDQSAI FRVLASILHL GNVYFQKHEE ADGQEVASVV SAQEIRVVAE
LLQISPEGLQ KAITYKVTET MRDKIYSPLS VENAVDARDA VAKILYSLIF HWLTERINAQ
VYPRQHSLSI SILDIYGFED LAFNSFEQLC INYANEYLQF FFNRIVFREE LEEYSREQIP
WQDITFSDNQ PCIDIIAAKP HGILRILDDQ SCFPQATDHT FLQKCHYHHG HNPLYVKPKM
PLPEFTIKHF AGRVTYQVYK FLDKNYDQVR QEVLDLFIQS RNKMVSNLFL AHADAMGQMR
KSSSVTRKYQ PPTVSSKFQQ SLLELVEKME RCNPFFVRCI KPNNMKRPAV FEDELVSSQL
RHSGVLETIR IRREGYPVKM PFYVFLFRYK SLVGLKQPPP ANGENCVIML SKLCPLRPGA
FHIGVTKEDV YQLLECKRER CRELAALTLQ RYARMFFVRK RFVEFRNKII GFQAHSRGYL
LRKRYVKMRE SLVRFRSYVR MYVNRKQYIK ELTKREVVNV THLVIPAELG ALLQTAAESQ
NNLSDCLALL QAPHIQEEAQ LTFPLDINNH PFYRYVQVHF REPKFGMLMV PLEFPLTKVE
DDLRREALEL FNMVLRFMGD PHLNGAQENL FGNYVIQRGL TSPGLRDEIL AQVVNQVWRN
TNLENAERGW LLLLACVSSF APSPKMEKHL LKFVSDHAPA GCQALLQHRL IQANQKMQQS
LGSFPEAART YPLSLLEWTA NRKKANMVLQ VHCFDGGSFL CPVHSWTSGE DLAGHILRHR
GVSDWWRGSS VLMKEQSQWV ELAGHDYVLD LIADLELPVD FPKQKSYFII STDNPAKHRF
LCSELTNTAG ASPFIILPAF LCPAESDTFS DGQTQRGMDR YLDSLFDPVL SDDGVNMEKA
ALSTRMKGGG GVGVAGETDA SPYSGGLPGL PALPAMPAVP GLPVVTGPEQ VVLTQQQQAI
INQQAIILAQ QMTMQAMAIQ QQMLSSFPPV APAPQTPPPH HHANPPQRSH TPSPVSFLPQ
RELEQPSDPG PNFQTGFFPS MHSKIYSSFI YPLITAVRPP ALTGHHQRCM EIKAILKMHK
ASPLPPPSPA EKQKSDGKKF AKKPDPHDEA MEILKDQMAN PPQPVNLNPL YKINAILTQT
SRRRSLCPPN RRKRKKELPV EEENIQTQLH SRTSDEYYTY SNVPWKLFMR KEVFYPKENL
NNPLILDLIF RQIVHDTFSE ACVRITQDER QKMKDLFAAE NKVDQASGTH DESVKKKVVA
MAKDSWEIYF SRLFPASGSV GTGVQVLSVS HKGIKLLKLV KSGSTTSDYF RVLRPYSYSD
ILFVSIPSKN MLEFNLTNEK LILFSAKAPQ VKHMIDYFLT ELKKDSEYVV AVRNYITENR
NHLSFHKGDI IRLQHMDGLE SGEKPGVDKG TLNIYFMSPN ETGWRFGAVF GRSGVFPSDY
VHPVAAPDFL FLPAERAEPR DRHGRVAASA AVAVAMGSAV AAHELELSTE VQTGILSSDY
NPNQYLMTEF AKKYFREAQR NRSPHSDQKA KKGKEARDPV DMVKFSKSPI HESLIDFSDS
GMNRVAADIS IAIMKFMGDF PMKGQTEQDL VATMLKLSSD HGLTKDEAYC QVMKQVTTNT
SSKHSCRDSC QRGWRLLYIL TAFHRCSDVM KPFLLRFLQD ACDSPGMPYQ GIAKACQENL
KRTFQYGGRI QYPNSMEIKA ILVAGRSSKR QLFLLPGGIE RHLKIKTCSV ALDAIEELCS
EMGLQRLEAL DEYAVFLVTH RGKNVRPLNK REYILDIATE AEPVDANYSL WFRRVVWSLA
LKLDNELYVT MHYNQVLPDY LKALLGVVPQ GKPSDQHMQQ IARLGALQHR AKDAIYLPTL
REVQECVPSQ FYSKQGSQQW LNMVTQHMQY VQPLNPHQAR AQFLGLVSAF PMFGSSFFYI
QSLSSSSIQA PCILAVNLNG LHFLNKDTHL QNDAMVRFPL KEVQSTRTQR PTSGSSYPYV
EIMIGDLLNQ RITQLQLEQG LELCRVIAMH MENMLSFREK RLTLPPSEIT LL
//
