ID A0A087XNX8_POEFO Unreviewed; 380 AA.
AC A0A087XNX8; A0A087YD82;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Actin-related protein 2/3 complex subunit {ECO:0000256|PIRNR:PIRNR038093};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000007481.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000007481.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Functions as component of the Arp2/3 complex which is
CC involved in regulation of actin polymerization and together with an
CC activating nucleation-promoting factor (NPF) mediates the formation of
CC branched actin networks. {ECO:0000256|PIRNR:PIRNR038093}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat ARPC1 family.
CC {ECO:0000256|ARBA:ARBA00006260, ECO:0000256|PIRNR:PIRNR038093}.
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DR EMBL; AYCK01017424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01027192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007544504.1; XM_007544442.2.
DR RefSeq; XP_007576292.1; XM_007576230.2.
DR STRING; 48698.ENSPFOP00000007481; -.
DR Ensembl; ENSPFOT00000007493.2; ENSPFOP00000007481.2; ENSPFOG00000007351.2.
DR Ensembl; ENSPFOT00000016007.1; ENSPFOP00000015985.2; ENSPFOG00000015894.1.
DR GeneID; 103132644; -.
DR GeneID; 103154813; -.
DR KEGG; pfor:103132644; -.
DR KEGG; pfor:103154813; -.
DR CTD; 10095; -.
DR eggNOG; KOG1523; Eukaryota.
DR GeneTree; ENSGT00950000183183; -.
DR OMA; TLKGSTW; -.
DR OrthoDB; 5471154at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR017383; ARPC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10709; ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR10709:SF10; ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 1B; 1.
DR Pfam; PF00400; WD40; 2.
DR PIRSF; PIRSF038093; ARP2/3_su1; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR038093}; Cytoplasm {ECO:0000256|PIRNR:PIRNR038093};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR038093};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 48..89
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 380 AA; 41955 MW; E7F147781F785D88 CRC64;
MAYHSFLLEP ISCHAWNKDR TQIALCPNNH EVHIYKKDGT KWTKIHELKE HNGQVTGIDW
APDSNRIVTC GADRNAYVWT LKEGSWKPTL VILRINRAAR CVKWSPKENK FAVGSSSRLI
SICYFEQEND WWVCKHIKKP IRSTILSLDW HPNNVLLAAG SCDFKCRVFS AYIKEVEEKP
GPTPWGSKMP FGEVLFESGG SGDAAPSSGG GGGWVHSVCF SHSGNRLAWT SHDSTVSVAE
GGKTGTVCSL SSETLPLLCV TFITENSLVA AGHDCYPMLY VYDGANASLT FGGKLDVPKQ
AASKDISARE RFKNLDRRAS ETQSTDKDLN TLHKNSISQI SMLEGGRNQC TKFCTTGMDG
GMGIWDVKSL ESAMKNLKIV
//
