ID A0A087XPS4_POEFO Unreviewed; 65 AA.
AC A0A087XPS4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Stress-associated endoplasmic reticulum protein {ECO:0000256|RuleBase:RU364120};
GN Name=SERP2 {ECO:0000313|Ensembl:ENSPFOP00000007777.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000007777.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000007777.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Interacts with target proteins during their translocation
CC into the lumen of the endoplasmic reticulum. Protects unfolded target
CC proteins against degradation during ER stress. May facilitate
CC glycosylation of target proteins after termination of ER stress. May
CC modulate the use of N-glycosylation sites on target proteins.
CC {ECO:0000256|ARBA:ARBA00037157}.
CC -!- FUNCTION: Interacts with target proteins during translocation into the
CC lumen of the endoplasmic reticulum. Protects unfolded target proteins
CC against degradation and facilitate correct glycosylation.
CC {ECO:0000256|RuleBase:RU364120}.
CC -!- SUBUNIT: Interacts with SEC61B, SEC61A1 and the SEC61 complex.
CC Interacts with CANX. {ECO:0000256|ARBA:ARBA00038831}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU364120}; Single-
CC pass membrane protein {ECO:0000256|RuleBase:RU364120}. Endoplasmic
CC reticulum membrane {ECO:0000256|RuleBase:RU364120}; Single-pass
CC membrane protein {ECO:0000256|RuleBase:RU364120}.
CC -!- SIMILARITY: Belongs to the RAMP4 family.
CC {ECO:0000256|ARBA:ARBA00005500, ECO:0000256|RuleBase:RU364120}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01006856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007557233.1; XM_007557171.2.
DR AlphaFoldDB; A0A087XPS4; -.
DR SMR; A0A087XPS4; -.
DR STRING; 48698.ENSPFOP00000007777; -.
DR Ensembl; ENSPFOT00000007789.2; ENSPFOP00000007777.1; ENSPFOG00000007861.2.
DR GeneID; 103141500; -.
DR KEGG; pfor:103141500; -.
DR CTD; 387923; -.
DR eggNOG; KOG3491; Eukaryota.
DR GeneTree; ENSGT00940000162467; -.
DR OMA; KNVNNRG; -.
DR OrthoDB; 1326375at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010580; ER_stress-assoc.
DR PANTHER; PTHR15601; STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4; 1.
DR PANTHER; PTHR15601:SF20; STRESS-ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN 2; 1.
DR Pfam; PF06624; RAMP4; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU364120};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364120};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364120};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364120};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT TRANSMEM 37..58
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364120"
SQ SEQUENCE 65 AA; 7431 MW; 4CA89CEF04336C06 CRC64;
MVAKQRIRMA NEKHSKNITQ RGNVAKTLRP QEEKYPVGPW LLALFVFVVC GSAIFQIIQS
IRMGM
//
