ID A0A087XQW3_POEFO Unreviewed; 511 AA.
AC A0A087XQW3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Occludin-like {ECO:0000313|Ensembl:ENSPFOP00000008166.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000008166.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000008166.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ELL/occludin family.
CC {ECO:0000256|ARBA:ARBA00009171, ECO:0000256|PROSITE-ProRule:PRU01324}.
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DR EMBL; AYCK01018303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007577345.1; XM_007577283.2.
DR RefSeq; XP_016519140.1; XM_016663654.1.
DR AlphaFoldDB; A0A087XQW3; -.
DR STRING; 48698.ENSPFOP00000008166; -.
DR Ensembl; ENSPFOT00000008178.2; ENSPFOP00000008166.2; ENSPFOG00000008118.2.
DR GeneID; 103155563; -.
DR KEGG; pfor:103155563; -.
DR CTD; 405757; -.
DR eggNOG; ENOG502QS9F; Eukaryota.
DR GeneTree; ENSGT00730000110989; -.
DR OMA; SNYDKPP; -.
DR OrthoDB; 5360956at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 6.10.140.340; -; 1.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR010844; Occludin_ELL.
DR PANTHER; PTHR23288:SF4; OCCLUDIN; 1.
DR PANTHER; PTHR23288; OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR Pfam; PF01284; MARVEL; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR SUPFAM; SSF144292; occludin/ELL-like; 1.
DR PROSITE; PS51225; MARVEL; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..262
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
FT DOMAIN 404..511
FT /note="OCEL"
FT /evidence="ECO:0000259|PROSITE:PS51980"
FT REGION 304..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 433..460
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 309..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..409
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 57294 MW; A286A752EB2FCEF8 CRC64;
MSSKPNGSPP PYEEDDRYNG PAQPAYSYYP DDEFQHFYRW SSPPGILKIM AIITLVLCVA
IFACVASTLA YDSQAMSNFG GTYGGSGGMY GGSGGMYGGS GGMYGGSSYY GAGTNYGYGS
IGGNYNDPRS GKGFMIAMAT FVFIFSLVVF IIIVSHQSLS QSRKFYLAVL IICPILALLM
LIATIVYLVA INPSSQTSTV YGSQIAALCA PYQQQQVSGI FQNQYLYHYC VVEPQEAIAV
VFGFLVTAAL IIMLVFALKT RQKINNYGKE NILWKKVKVV DDLAPPEDVE AWVNNVSAPP
QEALAADYPD YPDHSDHSDY PEKRRGSRSY LDDESNYDKP PISYTPQPMV ERPLQNEAPY
SSSSSEITSS TGRPKKRRAG RPRRADGQDY DTDYNSSGDE LDDNDFDSEF PPIANEQERN
SYKQEFDRDH LEYKDLQAEL DILNKDLSNL DRELDGLEEG SPQFLDTLDE YNKLKRIKKS
ADYQVKKRRC KYLKHKLNHI KKMVSDYDRR T
//
