ID A0A087XRQ0_POEFO Unreviewed; 744 AA.
AC A0A087XRQ0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Dipeptidyl-peptidase 4 {ECO:0000313|Ensembl:ENSPFOP00000008453.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000008453.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000008453.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Cell projection, invadopodium membrane {ECO:0000256|ARBA:ARBA00004341};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004341}.
CC Cell projection, lamellipodium membrane
CC {ECO:0000256|ARBA:ARBA00004485}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004485}.
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DR EMBL; AYCK01010693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XRQ0; -.
DR STRING; 48698.ENSPFOP00000008453; -.
DR Ensembl; ENSPFOT00000008465.2; ENSPFOP00000008453.2; ENSPFOG00000007915.2.
DR eggNOG; KOG2100; Eukaryota.
DR GeneTree; ENSGT00940000163944; -.
DR OMA; DKYKATT; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF205; DIPEPTIDYL PEPTIDASE 4; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..461
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 544..743
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 744 AA; 85303 MW; 284A8FD849737F49 CRC64;
MGTIAKVLLG VLGVAVVAVL IVVPTVIFLK DDGDDGNAGD VKMYGIMDVF NSSLKPASYN
MRWISDYEYL HKETDDSVTL INLKTNVSEV FLTKDKINEH QAFDFKLSAD RKYVAFMSNY
NKVWRHSFTA SYSLYDRESE KNITSSGIPD VVQFFAWAPA GNKLAYVWDN NVFLKTSPKS
PPEPITTNGE PNKILNGIPD WVYEEEMFSS NQGFWWSPGG KYLAYAEFND TLVHNIEYSW
YGEDQYPSTI SIPYPKPGTP NPVVKLFVVD TDNTTIVTEV VVPDSYKSIE HYLATVTWVT
DTRIAVQWLK RQQNQLILQI YDLNGTSWHP VEHLNLTSPG WIGRFSPPEP VFAPDGNSYY
LIMSDQAMYK HIHHVVGGKA SPITFGEWED IEILKVSKDN VYYLSNEQNR KPGGRNVYHW
TRNISYKCLT CTLQKECEYN TIYFSHNASY YRFSCHGPRI PQHFLVETST FKKIRVLEDN
KVFSDAIADI QMPTMRRGTL KIGRYNLWYQ MYLPPGFDES KKYPLLIDVY AGPCSQKVDF
RYRVGWSTYL ASTEKVIVAS FDGRGSGYQG DQLMFEIYKR LGTFEVEDQI TATKEFIKMG
FIDKDRVAIW GWSYGGYVSS MVLGSNSGVF KCGMAVAPVS KWEYYDTIYT ERYMMQPSEN
RDGYDNSTVT ARAKNFHSVQ YLLVHGTADD NVHFQQAAEI SEALVNEKVD FDAMWYTDKD
HGLDGFANMH VYIHMAKFLK NCFE
//
