ID   A0A087XRT7_POEFO        Unreviewed;       648 AA.
AC   A0A087XRT7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000008490.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000008490.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip.
CC       {ECO:0000256|RuleBase:RU367070}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC       {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
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DR   EMBL; AYCK01026200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01026201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007544038.1; XM_007543976.2.
DR   AlphaFoldDB; A0A087XRT7; -.
DR   STRING; 48698.ENSPFOP00000008490; -.
DR   Ensembl; ENSPFOT00000008502.2; ENSPFOP00000008490.2; ENSPFOG00000008355.2.
DR   GeneID; 103132208; -.
DR   KEGG; pfor:103132208; -.
DR   CTD; 797829; -.
DR   eggNOG; KOG4340; Eukaryota.
DR   GeneTree; ENSGT00390000010116; -.
DR   OMA; CCKHELY; -.
DR   OrthoDB; 5477075at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR   GO; GO:0031514; C:motile cilium; IEA:Ensembl.
DR   GO; GO:0070738; F:tubulin-glycine ligase activity; IEA:Ensembl.
DR   GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR   GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR   GO; GO:0001736; P:establishment of planar polarity; IEA:Ensembl.
DR   GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0036372; P:opsin transport; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR   PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|RuleBase:RU367070};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW   ECO:0000256|RuleBase:RU367070}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339,
KW   ECO:0000256|RuleBase:RU367070}.
FT   REPEAT          40..73
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   COILED          360..387
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   648 AA;  74825 MW;  1EF566733B776455 CRC64;
     MTAIKDGEYT ATIYTLIKDG QYVEAIHILN GQLQKHTKSR AALSLLGFCY YHIQDFSSAA
     ECYEQLTQLH PEVEEYKLYY AQSLYKAGAY SEATKASFVL DNPSSHTKMV KLQACIKFCE
     EDYSAAKLLL EQLPQDDPDY VYNMGCLLYQ EGKYEEACKK FMTAMQMLGY VPALSYNIAL
     TYYSMKNYPQ AVKYITEVID RGMSEHPELD VGVKTEGFDV HSVGNTLVLH QSALIEAFNL
     KAAIEYQMKN GQAAQEALTD MPPRSEEELD PVTLHNQALV NMEQKPSEGF EKMAFLLQQP
     SFPRVTFGNL LLLYCKHEYF DLAADVLAEN AHLTYKFLSP YMYEFLDALL TCQTAPEEAF
     RKFEEMNSKL TEQLRKLAKQ VQDTRHNRDD EVQSKTLQDY DLLQEKYVVV LMAQAKIYWN
     RENFQMVEKI FRKSVEFCND DDTWKLNVAH VLFMQNKYKE AISFYEPIVK TLYDSILDVS
     AVVLANLCVS YIMTSQNEEA EELMRKIEKE EEQISYNNPD KKVFHLCIVN LVIGTLYCAK
     GNYDFGISRV IKSLEPYNKK LGTDTWFYAK RCFLSLLENM SKHMVMLRDA VVKECIQFLE
     HCEVYGKGVP AIIEQPLEES HVHIGKNTVT YEARQLKALF YEVTGWNK
//