ID A0A087XSS8_POEFO Unreviewed; 613 AA.
AC A0A087XSS8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=RAP1 GTPase activating protein 2a {ECO:0000313|Ensembl:ENSPFOP00000008831.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000008831.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000008831.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01011552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01011553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XSS8; -.
DR STRING; 48698.ENSPFOP00000008831; -.
DR Ensembl; ENSPFOT00000008843.2; ENSPFOP00000008831.2; ENSPFOG00000008643.2.
DR eggNOG; KOG3686; Eukaryota.
DR GeneTree; ENSGT00940000165230; -.
DR OMA; FRRREIM; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 236..452
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 103..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 67816 MW; 6CB5A1FEB4CD851F CRC64;
MLRRRRSATF SGFGWIDKST LSALKGRKQE LLNISNVPLG ECPPSPPRTA PPSMKSADFF
DMLEKMQDDY IPYPRIEDVL EKGGPYPQVI LPQFGGYWIE DAEAPAGTPS SSESSFCEEE
DGDEGMSPGG AHSYRLECNS TARAYRKHFL GKEHMNYYCS GSSIGNLIMS LKHEEAQGQE
FLRIMLRSRT KTVHDRISLA GISQLPSVPQ IAKLLCDDAT GLRFSPVLYP RGSQLIVAYD
EHEVNNTFKF GVIYQKFGQT SEEELFGNNE ETPAFKEFLS ILGDNIELQD FKGFRGGLDV
SHGQTGSESV YTVFRHREIM FHVSTKLPFT EGDVQQLQRK RHIGNDIVAA VFQEESTPFV
PDMIASNFLH AYVLVQVENP CTDHTTYKVS VTAREDVPPF GPPLPNPAVF KKGPEFREFL
LTKLINAENA CYKSDKFAKL EGRTRAALLD NLHDELHRQS QAVLGLGQMG EEDKLENGGH
GGLLESFKRA MRVRSHSMET VVGSHRHRSP GVAGGVPASL SGGGLPQSTS ECTKSTFTPP
VLSAKSPLKS PVKRRSGLFP RLHSSTDAPS DKHTRSDHKP AEICPHSQEV RSETSSNPSS
PEICPNKERS AGS
//
