ID A0A087XTK3_POEFO Unreviewed; 4934 AA.
AC A0A087XTK3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 {ECO:0000313|Ensembl:ENSPFOP00000009106.1};
GN Name=HERC1 {ECO:0000313|Ensembl:ENSPFOP00000009106.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000009106.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000009106.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01023943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01023944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000009106; -.
DR Ensembl; ENSPFOT00000009118.1; ENSPFOP00000009106.1; ENSPFOG00000007797.1.
DR eggNOG; KOG1426; Eukaryota.
DR GeneTree; ENSGT00940000155907; -.
DR OMA; LAICCQN; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd12881; SPRY_HERC1; 1.
DR CDD; cd14401; UBA_HERC1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035768; SPRY_HERC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR22872:SF6; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 10.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 14.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 379..428
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 429..483
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 484..536
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 537..586
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 588..639
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 640..690
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 691..743
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 2013..2204
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 3483..3524
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3684..3715
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3812..3853
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 4068..4116
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4117..4171
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4172..4223
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4224..4275
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4277..4328
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4329..4382
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4383..4434
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 4574..4921
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 125..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1327..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1507..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2260..2308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2432..2469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2511..2532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2651..2723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2740..2802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2902..2928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1507..1530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2276..2308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2453..2469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2677..2717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2740..2793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4884
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4934 AA; 534832 MW; EAAB6F2AC08B96B5 CRC64;
MALMIPPVKL KWLEHLNSSW ITEDSESIAT RNGVSALYAK LLANKEAVLL PQQVLCLKGP
QLPDFERESL SSDEQEHYLD ALLGSQLALA KMVCSDSPFA AALRKRVLVL QRVFYALSNK
YHDKGKVKQQ QHSPESSAGA ADPHAVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP
PPPGPGGAPG DGINLCNDVI HTAIDVVSSL PPLSLANESK IPPMGLDCLA QVTTFLKGVT
MPNSGADILG RRLASELLLG LASQRGSLRY LLEWIEMALA ASAVVSAMEK NAAPHCQEGL
MGYDCFMNIL MQMRRSLGST ADRSQWREPT RTPDGLCSLY EAALCLFEEV CRMASDYSRT
CVSPDSIQTG EAPVVSETCE VYVWGSNSSH QLVEGTQEKI LQPKLAASFA DAQTIEAGQY
CTFVISSDGS VRACGKGSYG RLGLGDSNNQ STLKKLTFEP HRAIKKVSSS KGSDGHTLAF
TTEGEVFSWG DGDYGKLGHG NSSTQKYPKL IQGPLQGKVV RCFKAGYRHS AAVSEDGELY
TWGEGDFGRL GHGDSNSRNI PTLVKDISNV GEVSCGSSHT IALSKDGRTV WSFGGGDNGK
LGHGDTNRVY KPKVVEALQG MFIRKVCAGS QSSLALTSTG QVFAWGCGAC LGCGSSEATA
LRPKLIEELA TTRVVDVSIG DSHCLALSHD NEVYAWGNNS MGQCGQGNST GPITKPKKVV
GLDGVAIQQI SAGTSHSLAW TALPRDRQVV AWHRPYCVDL EESTFSHLRS FLERYCDGIN
SDVPPLPFPS SREHHNFLKL CLRLLSNHLA LALAGGVATS ILGRQARPLR NLLFRLMDAS
VPDEIQEAVI ETLSVGATML LPPLRERMEL LHSLLPQGPD RWESLSKGQR MQLDIILTSL
QDHTHVASLL GYSAPADGPD APAPGPAFAP DPGYGAVGSH PDTHLAEILM KTLLRNLGFY
TDQALGELEK NSDKLQQRAS SSDSSQPAHL HQLLCSLQKQ LLAYCHINAI TENSSSVALL
HKHLQLLLPH ATDIFSRSAA LIQDSSGNGS IREKLQDVIY VSAAGSMLCQ IVNSLLLLPV
AVVRPLLSHL LDLLPPLDRL NRLLPAAAPL EDQELQWPLH GASDLAEPAS GLALPAAALC
WVWLVDLERT AALLVGRCLG GMLQGAAASP EENHAAYWLK TPLFSNGLET DIPQLDWVIG
SLLEAALSGN EEQKPLDRPL RPDLSLLLDL ALGSSKEPAN SLWINMQDYA ISKDWDNASL
NNESLLDTVS RFCLAALLKH SGLLGPACGE GRYQPSKSLA EVYRSVYKVR NRLLACKNLD
FIQTRSSSRE RRISDNQDSL DMDPQENSFT RTIDEEAELE ERADREREEG HQDQDEEEED
REHEVMTAGK IFQCFLSARE VARSRERERA SSGTGPGSGS TSRSAAAASG SGEEEAAQSQ
EERRGSAGLP EGQDLYTAAC NSVIHRCALL LLGVSPVLGE LGKQNQEDGP AQSATGTQDC
LSFMTRSESL SAESRSVQSS PSYRLIKSRS ESDLSQPESD EESYTLSGRR NVDLDLASSQ
KKRGMLHSSP DSLAESWFRS KLSRQRSYGS AHSYGESDLD LSRSLGVHAL IDNMVSFISG
DVGLAPAFKE PEEGMSTNPQ AAILAMEQQQ SRAELRLEAL HQIVVLISGM EEKGSQQGGA
ERPGGAFQSS SLLTSVRLQF LAGCFGLGTV GSGLKRENVQ LHHYQDGIKA AKRSLQMEIQ
TAVHKIYQQL SVTLERALQA NKHHIEAQQR LLLVTVFALS VRYQPVDVSL AISSGLLNVL
SQLCGTETML GQPLQLLQKP GVSQLSTALK VASTRLLQIL AISTGTYADK LSPKVVQALL
DLLCSQLKNL LAQAGGSRLA AGKNPDDSKT DDCPDSDKKD FRALIRKQHT AELHLGDFLV
FLRRVVSSKA IQSKMASPKW TEVLLNIAAQ KCCSGVPLVG NMRTRLLALH VLEAVLPACE
ANMEDDQLTQ VVDRLFSLLS DCMWEAPVAQ AKHSIQIKEK LQELKLQQQG EAEEEDENLP
IQEVSFDPEK AQCCVVENGQ GLTHGSGGKG YGLASTGISS GCYQWKFYIV KENRGNEGTC
VGVSRWPVHD FNHRTTSDMW LYRAYSGNLY HNGEQTLTLS SFTQGDFITC VLDMEARTVS
FSKNGEEPKL AFEDVDAAEL FPCVMFYSSN PGEKVKICDM QMRGTPRDLL PGDPVCSPTP
TVLVEATAQL VRILHRTDRW TPRINSAIIQ RLQKIKPCFR DAATGGPAGG QRLKKSRSVQ
SREEHDAQRE SPDAPPRAEE DRGRHGRQHG LADLAEPHLR SLCCDVWPVL AVIGGADGGL
RVGGRCVHKQ TGRHATLLGV AKEGSSSAKV QWDEAEITIS FPTFWSPSDT PLYNLEPCEP
LPFDVGRFRG LTSSLLLDLT YLASIHEETA AKLGGRRHDR KHRNAASVGH EPSCADDRPD
GQKDAAASEL RVSHSLEEVK AHLAPNSKSE SEISSVACGN EALFGPAPNA AAEAGRKKGH
DHGGRHEAPP ISTQSEIHAV QLSYLYLGAM KTLSALLSCS KYAELLLIPK VVPEAAPSGH
NADLNASGGA APPSPVFQEE VEMRTALQFL MRHMVKRAVM RSPIKRALGL ADLERAQAMI
YKLVVNGLLD EPSGGKSRPG ARSEPEGEGE GGEGEQLAQT PITTSPSASS TTSFMSSSLE
DTTTATTPVT DTETVPASES PGVMPLSLLR QMFSSYPTTT LVPTRRAQTP PVSSLPTSPS
DEVGRRQSLT SPDSQPCRPQ NRAGTSLSDP SSRLSTSPPP PAIAVPLLEM GFTLRQISKA
LEATGARGEA DAQNITVLAM WMIEHPGTED ERDEPHTRSG ALVVDAPDSA SCPGAMASSG
GKSLDRSPYL CCPGDVASAD ASELEEGFSD SPEGLEQDSA AASSCTSLRG RSAAGRKHRF
DLAARTLLAR AAGLYRSVQA HHSQARRDAA APQQQDPGAL YDFNLDEELE MDLDEETMEA
MFGQDLASDT DILGMWIPEV LDWPTWHVCE ADDRDEVVVC ELCEANVANF NQHMKKSHPG
CGRSANRQGY RSNGSYVDGW FGGECGSGNP YYLLCGGCRD KYLAIKSKAR VPAAERYKGQ
APDLLGKQDS VYEEDWDMLD VDEDEKLTGE EEFELLSGPL GLSERRVVPE PVQFPDSDPL
GASVAMVTAT NSMEETLLQI GCQTSVDKSS SGRMTLGEQA AALQNPHDRV MALRRVTAAA
QVLLARTMVM RALSLLSVSG SSCSLAAGLE SLGLTDIRTL VRLMCLAAAG RAGLSTGPAV
GAGPSERPRG AAKASKPISC LAYLSTAVGC LASNSPNAAK LLVQLCTQNL ISAAIGMNLT
TVDDPIQRKF LPSFLRGVAE ENKLITSPNF VVTQALVALL ADKGARLRPV YDKADLEKRG
PLELANALAA CCLSSRLSSQ HRQWAAQQLV RTLAAHDRDN SQSRPQTFAD MAGDLRKCSF
IKLEAHQSRV ITCGWCSKKG LLATSGGDGT VRVWNVTKSQ YTLQQTCVFN KDDVSSEDGM
SALGSPSDPC LSPLAWSVTG KYLASAMEKM VNIWQVNGGK GLLDVQPHWV SALAWPEEEA
ESLWCSEPKD MLLVGRMDGS LGLIEVLDAS DMHRSELEHC YRKDVAVMHI AWYSEDRPFA
VGYADGKLLI GSKEPLEKGA VVVIDAHKES ITSMKWSPNG QILLSCAKEE TVKLWAAPDR
DSGPGSGWRC LQSLRHPSLV NGVAWCGLPG RGPRPLSMLA ICCQNGLVSV WTVPQEICHF
PESSDSETLW ENDAKPKSPR WAEDGAVSVL QLKGHITPVR TLAFSPDGLA LASGGVGGLM
NIWSLRDGSV LQTVVAGSGA IQNIVWIPDV GVAVCSNRSK DVLVVNCSKE FMASNHVLAT
CRSALKRQGV VGLNVAPCMR AFLERLPVML QEQYAYEKPH VVCGEQLVHS PYMQCLASLA
VGLHLDQLLC RPPAPPHLRR CPPESGTAVW STSEWAWLDC FSTTVKAAEA LARGATFPDS
FCVPDLEPVP KEEMALVMDN GKWAAGMDEQ IMSWATSRPE DWHLGGKCDV FLWGAGRHGQ
LAEAGRNILV PTTAPSFSQA QQVVCGQNCT FVIQPNGSVL ACGEGSYGRL GQGNSDDLHV
LTIISALQGF VVTQLVTSCG SDGHSMALTE SGEVFSWGDG DYGKLGHGNS DRQRRPRQIE
ALQGEEVVQM SCGFKHSAVV TADGKLFTFG NGDYGRLGLG NTSNKKLPEK VTALEGYQVG
QVACGLNHTL VVSADGSMVW AFGDGDYGKL GLGNSTAKSS PQKVDILCGT GIQKVACGTQ
FSVALTKDGK VYTFGQVKDR LIGLPEGRAR NHNRPQQVPA LSGIHIQDVA VGAEHTLVLS
STGDVYAWGS NSEGQLGLGH TNHVREPTLV TALQGKNINQ ISAGRCHSAA WTAPCVPPRA
PGSSVPLQLG LPVAVPPQYS GLKEVSMEAV RARLRLLYHF SDLMYSSWRL LNLSPNNQSC
TSHYNAGTWG IVQGQLRPLL APRVYTLPMV RSIGKTMVQG KNYGPQITVK RISTRGRKCK
PIFVQIARQV VKLNASDLRL PSRAWKVKLV GEGADDAGGV FDDTITEMCQ ELETGVVDLL
IPSPNATAEV GYNRDRFLFN PSACLDEHMI QFKFLGILMG VAVRTKKPLD LHLAPLVWKQ
LCCIPLQLED LEEVDLLYVQ TLKSILHIED SGITEDSFHE MIPLDSFVGQ SADGKMVPII
PGGGSIPLSF SNRKEYVERA VEYRLHEIDR QVAAVREGMS WIVPVPLLSL LTARQLEQMV
CGMPEICCEV LKKVVRYREV DEQHALVQWF WQTLEEFSND ERVLFMRFVS GRSRLPANTA
DISQRFQIMK VDRPYDSLPT SQTCFFQLRL PPYSSQAVMA ERLRYAINNC RSIDMDNYML
SRNVDNAEGS DTDY
//
