ID A0A087XU01_POEFO Unreviewed; 436 AA.
AC A0A087XU01; A0A087X9U8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=vesicle-fusing ATPase {ECO:0000256|ARBA:ARBA00012674};
DE EC=3.6.4.6 {ECO:0000256|ARBA:ARBA00012674};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000009254.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000009254.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
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DR EMBL; AYCK01007412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01015019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007558540.1; XM_007558478.2.
DR RefSeq; XP_007573097.1; XM_007573035.2.
DR STRING; 48698.ENSPFOP00000002551; -.
DR Ensembl; ENSPFOT00000002555.2; ENSPFOP00000002551.2; ENSPFOG00000002356.2.
DR Ensembl; ENSPFOT00000009266.2; ENSPFOP00000009254.2; ENSPFOG00000009079.2.
DR GeneID; 103142423; -.
DR GeneID; 103152541; -.
DR KEGG; pfor:103142423; -.
DR KEGG; pfor:103152541; -.
DR CTD; 27183; -.
DR eggNOG; KOG0739; Eukaryota.
DR GeneTree; ENSGT00940000157319; -.
DR OrthoDB; 276256at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd02678; MIT_VPS4; 1.
DR CDD; cd19521; RecA-like_VPS4; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015415; Spast_Vps4_C.
DR InterPro; IPR045253; VPS4_MIT.
DR PANTHER; PTHR23074; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23074:SF177; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF04212; MIT; 1.
DR Pfam; PF09336; Vps4_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00745; MIT; 1.
DR SUPFAM; SSF116846; MIT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003651};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003651};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 2..80
FT /note="MIT"
FT /evidence="ECO:0000259|SMART:SM00745"
FT DOMAIN 158..294
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 75..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 48953 MW; A0EDA8165A7E3940 CRC64;
MTTSTLQKAI DLVTKATEED KAKNYEEALR LYQHAVEYFL HAIKYEAHSD KAKESIRAKC
MQYLDRAEKL KDYLKNKDKQ GKKPVKEAQS NDKSDSDSEG ENPEKKKLQE QLMGAIVMEK
PNVRWNDVAG LEGAKEALKE AVILPIKFPH LFTGKRTPWR GILLFGPPGT GKSYLAKAVA
TEANNSTFFS VSSSDLMSKW LGESEKLVKN LFDLARQHKP SIIFIDEVDS LCGSRNENES
EAARRIKTEF LVQMQGVGNN NDGILVLGAT NIPWVLDAAI RRRFEKRIYI PLPEEPARAQ
MFRLHLGNTP HSLSDADLRE LARKTDGYSG ADISIIVRDA LMQPVRKVQS ATHFKKVRGP
SRSNNQVMVD DLLTPCSPGD PAAIEMTWLD VPSDKLLEPI VCMSDMLRSL STTRPTVNTE
DLLKVKKFTD DFGMEG
//
