ID A0A087XU94_POEFO Unreviewed; 2271 AA.
AC A0A087XU94;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=ATP-binding cassette, sub-family A (ABC1), member 4a {ECO:0000313|Ensembl:ENSPFOP00000009347.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000009347.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000009347.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AYCK01007995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01007996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000009347; -.
DR Ensembl; ENSPFOT00000009360.2; ENSPFOP00000009347.2; ENSPFOG00000008477.2.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000155624; -.
DR OMA; RDELTQN; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF190; RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1331..1349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1361..1382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1669..1691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1721..1738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1750..1768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1780..1805
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 925..1156
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1927..2159
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 889..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2271 AA; 257741 MW; 4103BD07CF7AB5D4 CRC64;
MGSGGQVRLL LWKNWTIRRR QRIRFFVEIM WPVMLFMGLV WLRRVNPLYR QHECHFPNKA
MPSAGILPWI QGIVCNANNP CFQYPTRGES PGLVSNYNNS ILARFYSDAE ELLFSDPEFL
QVGRLWRELN AMSNFMDMLR THPEKVSGRG VKVEAILKDD ETLTSFLLRD IPLTESVVYH
LVNAQIRPEQ FAFGVPDLHL KDIACSLSLL ERFLIFQSHR GLYSVRNAMC ILTPQRLQII
EDRFYVNVDF FKLFRLLPHV LDNYSDGIDI HFWVRIVSTA SDRLRDLFHR SSSREFIQVV
TPLFQKNLSF REVMAAASSL VCGYTEGAFS RVASFNWYED NNYKAFLGIT SGWAKGDYTY
DNSTTPFCND LMKELESSPA TWIVWNSVKP MLMGRILYAP DSPAVKQIIR NANTTFEELE
RLRTMGKAWE EVAPQIWAFF QDGVQVKMIR DTIRNPSVMD FIDRSLEDAP FSSEHILNFL
HNGPPEERRY DMPDFDWRDV FNLTDRVVRM LNQYGDCLIL DKFIPLPDED AVTHRALDLL
EGGKFWAGLV FTNMFSWTTS VPPHVKFKIR MDIDIVERTN KVKDRYWDPG PRADPMDDFR
YIWGGFAYLQ DIIEHGIIRT HTGKEWPLGV YLQQFPYPCY VDDLFMLTLN RCFPIFMVLA
WVYSVSMVVK SIVLEKELRL KETLKTIGVT NGVIWSTWFI DSFFMMGTST ALLTAIIMGG
RVLNYSDPVI LFLFLLSFTT ATIMQCFLFS IFFNQANLAA ACCGIIYFAL YLPHIFCFTW
QERITKDMKI MASLLSQVAF GFGTEYLSRY EEQGMGLQWD NIQTSPLEGD EFSFLTSICM
MGLDTVLYAA LAWYLDNVFP GQYGIGRPFY FPLLPCYWLN SVAPASDKEQ GEKKAAAETA
EQVEPQVSTE EPFFEAEPAD LVKGVCIQNL VKVFSSCSSP AVDGLSINFY ESQITAFLGH
NGAGKTTTMS VLTGMFPPTS GTATIYGKDI RTDMDSIRMS LGMCPQYNIL FQHMTVAEHI
LFYALLKGRP IAEAEEEVEN MLQDLGLPHK RDELTQNLSG GMQRKLSVAL AFVGGAKVVI
LDEPTSGVDP YSRRSIWDLL LKYRLGRTVI MSTHHMDEAD LLSDRVAIIS QGRLYCCGSP
IFLKNCFGAG FYLTLVRRMK HEPPNVRNWE NDCLCKCSKC SKFKVNQEES HTPDRQLDGN
MESITALVHH HVPQARLIEA IGQELTFLLP NRDFQPRAYA SLFRELEETL VDIGLSSFGV
SDTSLEEIFL KVTANGNATN KKCSQGMAAI LDNELRADWE SLTFQLGFLT SETNGHGPNE
FPEGSEGKGS YQVRGVCLII KQVLALLIKR WHHATRSYKD FIAQIVLPAS FVFLALMFTL
IVPPFGEYPS VTLTPWMYGR QYTFFSNERP MDAQMRYFGE VLLDKPGFGT RCMADEPLED
FPCNNITTEW EMLMVNPSLI EMLESPKWTP LRPSPECQCS TSKKLTMLPV CPEGAGGLPP
PQRIQSTGDV LFDLTGRNIS DYLVKTYPTL IRTSLKSKYW VNEQRYGGIS VGGQLPVLGV
QPKTLQDLAA QLGQLLNLTG GQYSKETLKG IGKFLRYMET ENNVKVWYNN KGWHAMVSFM
NVANNAILRA NLPKGADLNE YGITVVNHPL NLTKEQLSEI TVLTTSVDAV VAICVIFAMS
FVPASFILYL IQERVTQAKH LQFVSGVSPL VYWTANFLWD MVNYSISAAM VVEIFLFFDK
RCYTSPANLQ PLIALLMLYG WSVTPMMYPM SYVFSVPSTA YVSLSCINLF IGINSSAITF
ILDLFESTTA LYRFNQMLKT VLLIFPHYCL GRGLIDMAMN QAVTDVYARF GEDYSPDPFN
WDFIGKNLFC MATEGFVYFI LNILFQYRFF LDHWIPDSPK PHMLEEDIDV AEERERIHRS
KNTFDILRIK DLSKTYRGTI IPAVDRICVG VSPGECFGLL GVNGAGKTTT FKMLTGDIDV
TSGEATVSGY SILTNILDVH QNMGYCPQFG AIDELLTGRE HLHLYARLRG VPESEISRVA
EWAIQKLGLS EYAGRSAGTY SGGNKRKLST AIAMIGCPAL VLLDEPTTGM DPLSRRFLWN
SIMSVIQDRR AVVLTSHSME ECEALCTRLA IMVNGSFKCL GTIQHLKYKF GDGYVVTMKI
RAAKPGCLPN LNPAEAFMES TFPGSIQREK HYNTLQYKIS SPSLARIFQM VLANKDKLNI
EDYSVSQTTL DQVFVNFAKQ QSREDDTIVL HPKAAGAQRY IETTAIKSYR K
//
