ID   A0A087XVJ2_POEFO        Unreviewed;       657 AA.
AC   A0A087XVJ2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=GRAM domain containing 1C {ECO:0000313|Ensembl:ENSPFOP00000009795.2};
GN   Name=GRAMD1C {ECO:0000313|Ensembl:ENSPFOP00000009795.2};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000009795.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000009795.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC       Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC       Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
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DR   EMBL; AYCK01005758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007554615.1; XM_007554553.2.
DR   RefSeq; XP_007554616.1; XM_007554554.2.
DR   AlphaFoldDB; A0A087XVJ2; -.
DR   STRING; 48698.ENSPFOP00000009795; -.
DR   Ensembl; ENSPFOT00000009810.2; ENSPFOP00000009795.2; ENSPFOG00000009784.2.
DR   GeneID; 103139755; -.
DR   KEGG; pfor:103139755; -.
DR   CTD; 54762; -.
DR   eggNOG; KOG1032; Eukaryota.
DR   GeneTree; ENSGT00940000158013; -.
DR   OMA; HISANKM; -.
DR   OrthoDB; 45896at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044232; C:organelle membrane contact site; IEA:UniProt.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR031968; VASt.
DR   PANTHER; PTHR23319:SF1; PROTEIN ASTER-C; 1.
DR   PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF16016; VASt; 1.
DR   SMART; SM00568; GRAM; 1.
DR   PROSITE; PS51778; VAST; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        552..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          323..494
FT                   /note="VASt"
FT                   /evidence="ECO:0000259|PROSITE:PS51778"
FT   REGION          240..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          514..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..272
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..307
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   657 AA;  75107 MW;  4F6F425F6C0BA068 CRC64;
     MDQLSNRSGV GSDDITDETG SLLDVQLSSD EDSSDALGPC LAVPQSPLPS YKQRVEEFKR
     LFKELPDSEI LILDYPCALH RDILLQGRLY LSENWICFYS YVFRGTKIIL SLKDITTMSR
     EKTARLIPNA IQICTRTEKY FFASFSAREK SYLSVFRIWQ NSLLDKTLTC PELWQMIKQH
     YGYDLGLNNE EMENLQVLTE STGQTSLQQK FISAADEGLG RPERPNSLLL PVVEHVPLQS
     STPQGEEMPS PMSSPRTTNT VESHNSPSLH RSPTLPLARH PAERLSKRST QSLDLNANEN
     LLEQSGSETS EEVEDRIDKS EEPGRLYLNK VFHMSASKLF ELLFTDSSFT QRFMEIRSIT
     NPSSTAWQKD DSGNDKRVLS YTVAINNPLI GKFSTATENQ TLSKESREGQ YYQVDAVVYT
     HDVPYHDHFY TQNRYYIIRV SKRKCRLRVY SDVKYSKPTF GLIKTFITKN SWTGIEDYFR
     QLEAELLEEE SEMNQAVGES GKAGVRRRRR TFSRTLLDHG KPGKQSGQDP EHRDGNMGPM
     DTTGLQRWST TAIVVSMSVI LLILIVLNLG LFFKLWAMED VAHRMYLTTK HRLRERMETS
     FGPKYGPKPL PGFRTNEDMQ LLKTVLQDSI LLLEQLRTSL VVLQQNFAMA NQTATQQ
//