ID A0A087XVP5_POEFO Unreviewed; 394 AA.
AC A0A087XVP5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=glutaminyl-peptide cyclotransferase {ECO:0000256|ARBA:ARBA00012012};
DE EC=2.3.2.5 {ECO:0000256|ARBA:ARBA00012012};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000009848.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000009848.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-
CC [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736,
CC Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722,
CC ChEBI:CHEBI:87215; EC=2.3.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000001};
CC -!- SIMILARITY: Belongs to the glutaminyl-peptide cyclotransferase family.
CC {ECO:0000256|ARBA:ARBA00006014}.
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DR EMBL; AYCK01003502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007549532.1; XM_007549470.2.
DR AlphaFoldDB; A0A087XVP5; -.
DR STRING; 48698.ENSPFOP00000009848; -.
DR MEROPS; M28.016; -.
DR Ensembl; ENSPFOT00000009863.1; ENSPFOP00000009848.1; ENSPFOG00000009835.1.
DR GeneID; 103136297; -.
DR KEGG; pfor:103136297; -.
DR CTD; 561142; -.
DR eggNOG; KOG3946; Eukaryota.
DR GeneTree; ENSGT00390000003107; -.
DR OMA; CDRVRMP; -.
DR OrthoDB; 3091175at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016603; F:glutaminyl-peptide cyclotransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03880; M28_QC_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR037457; M28_QC.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR040234; QC/QCL.
DR PANTHER; PTHR12283; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR PANTHER; PTHR12283:SF3; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-LIKE PROTEIN; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 155..387
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 394 AA; 43537 MW; 2C3AB0ED3761F564 CRC64;
MSRSSRRYNK PPQQSNGGSL PGCDRVRIPR ARVLLLGLLS VLVLAVVLSV YLSNDTSGGH
GSRLPAVDLV KDRLSHKPSK VSVAQIRRLA SLVDGARLWE THLRPILIER LPGTRGSLAV
QQHIASTLSS LSAGWSVDLD SFQSPTPRGQ VTFTNVVAVL DPAAPRRLLL ACHYDSKALP
PDPRAPERVF LGASDSAVPC AMILELATSL DAQLRSFKQQ KLPVTLQLVF FDGEESFEEW
TATDSLYGSR HLAELLANTP HPAASPHATA LQAVDLFVLL DLLGGPDPLI ANHFDNTARW
FDRLISAEKR LHRQGLLMSH PSEQTYFRKD VYLGPVQDDH IPFLHKGVPV LHIIATPFPQ
FWHTLDDTEE NMHRPTVENL TKIMAVFLAE YLGL
//
