ID A0A087XW21_POEFO Unreviewed; 820 AA.
AC A0A087XW21;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Disintegrin and metalloproteinase domain-containing protein 9-like {ECO:0000313|Ensembl:ENSPFOP00000009974.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000009974.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000009974.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AYCK01007305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007558430.1; XM_007558368.2.
DR AlphaFoldDB; A0A087XW21; -.
DR STRING; 48698.ENSPFOP00000009974; -.
DR Ensembl; ENSPFOT00000009989.1; ENSPFOP00000009974.1; ENSPFOG00000009790.1.
DR GeneID; 103142341; -.
DR KEGG; pfor:103142341; -.
DR eggNOG; KOG3607; Eukaryota.
DR GeneTree; ENSGT00940000166115; -.
DR OMA; NGSTAYC; -.
DR OrthoDB; 5406290at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR018358; Disintegrin_CS.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF244; ZGC:174164 PROTEIN; 1.
DR Pfam; PF08516; ADAM_CR; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR PRINTS; PR00289; DISINTEGRIN.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS00427; DISINTEGRIN_1; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..820
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001833608"
FT TRANSMEM 698..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 210..406
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 414..500
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT DOMAIN 641..675
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 735..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 348
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 352
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 358
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT DISULFID 365..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT DISULFID 472..492
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT DISULFID 665..674
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 820 AA; 89100 MW; 251B2B1AA16979F0 CRC64;
MIIRKPIFIA FILHLCISEI ENKEDFSGFT SKLPKYSIVK PQVINNRWTR SLNRTSQTEE
AYGDKVSYTL MINNKEHILH LEKNRGFLHP NFVQYSREAS GNYNTSYPRQ HVNCYYHGSV
EGYEGSVVAL STCSGLRGVI LLENETFGLE PVPASTTNEH ALYLLKDSHS EPVTCGVVGE
ATSTPNYEPF EPAQSMTSLL RRKRALPQTS YVELVLVVDN LRYNYKQQNE TAVREEMVQM
ANLLDGYYKP LNIRVVLVGL EIFKQSNPFS VDGSAGQVLG EFVKWRKSTL LPKIRHDIGQ
LIVGRSGSYG GGVLGMAYVG TVCSVASSGG INVYSNDNLN FVSTVVAHEM GHNLGMNHDS
SGCTCNGKSC IMSAGAGGAV QFSKCSEQDF ESLIVRGGGV CLRNQPSASD VIGTAECGNG
RLDKGEECDC GTKEECKNEC CDAATCKLTR GSSCAHGYCC EKCQFKVAGT QCRKSLDVCD
LPEYCNGKSG FCPQDFYIMD GLPCKNDAAY CYEGRCQTYD YQCLQLFGSG AKKADDICFE
YENVKGNVFG NCGITSSGGY IKCTVANAKC GKVQCTNVDL NNHPAGAQIS IEIVQGSKCI
NADFNLGTDV LDPAYVNPGS PCDNGKTCVD FKCVNASVLD PKLGCDAQTT CSGRGVCNDQ
GHCHCDNGWA PPNCNKAGRG GSIDSGPAMI DYSLRNGLLI FFLLIVPLLV AAILVLLYVF
KRDSLDICLK RRKKTRSTGN RNANAPTNGN VQTDVTIQPP RQVPPERPPA PTVTSVPISG
FRYGEVDYWS QEANEAPSRP PAPVQGPGVP RPIPVKDISS
//
