ID A0A087XXR0_POEFO Unreviewed; 1130 AA.
AC A0A087XXR0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000010563.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000010563.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR EMBL; AYCK01001308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XXR0; -.
DR STRING; 48698.ENSPFOP00000010563; -.
DR Ensembl; ENSPFOT00000010578.2; ENSPFOP00000010563.2; ENSPFOG00000010224.2.
DR eggNOG; KOG2041; Eukaryota.
DR GeneTree; ENSGT00940000155745; -.
DR OMA; CVSETHM; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039857; Ift122/121.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017233; WDR35.
DR PANTHER; PTHR12764:SF5; LD29485P; 1.
DR PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1130
FT /note="WD repeat-containing protein 35"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001833691"
FT DOMAIN 86..138
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1130 AA; 127577 MW; 9FE52DB4278288EC CRC64;
MSKIKMISLF ILETPSGAVQ VVTWNERNEK LTTSDQNGLI IVWMLYKGAW YEEMINNRNK
SVVRSMSWNA DGQKICIVYE DGAVIVGSVD GNRIWGKELK GSQLAHVAWS PDSKILLFGM
ANGEVHIYDN QGNFIMKMNI SCLAGATGAV SLAGIHWYAG AGGYSEPDSP CLAICFDNGR
CQIMRYENDE NPVYIDALMN VISIQWNHCG SVLAVAGSLR ATNMDKEFNV VQFYTPFGEH
LRTLKVSGKH LSGISWEGGG LRIALAVDSY IYFANIRPDY KWGYCCSTVV YAYTKPERQE
YCVVYWDTKN NEKFVKYVKN LISITTSGDF CILASKADEK QPQDDVGSET MNLARYVLIL
CNSIGTPLDS KYIDIEPLFV TMTRTHVITA SKEAFYLWQY RVAKKLTALE INQVTRTKKG
GRERFYHIDS NPSGGNDDDP DISNAFATTR DPICCITATD KTLIVGRESG IIQRYTLPNV
ALVQKYSSNS RAHYLSLNCN SSRLAIIDIS GLLTLLDLEV RPPGSEGTGD QAAAGDPSKF
ERKDVWDLKW ANDNPDLFAV MEKTRMYVFR NLDPEEPIQT SGYICNFEDL EIKSVLLDEI
MKNPERPNKD NLFNFEIRSL RDSRALIEKV GIEDASQFIE DNPHPRLWHL LAEAALQKLD
LKTAEEAFVR CKDYPGIQFV KRLGNLQSEP MKQAEVAAYF GRFEEAESMY LHMDRRDLAI
NLRIKLGDWF KVLQLLDTGS GYSDDALLAQ ANNGIGDYFA DRQKWVKAVP YYLKGRNQER
LADCYYKLED YNGLEQLAAD LPENHKLLPE IGEMFATVGM CEQAVKAYLK SNQPKAAVDT
CVHLNQWNKA VELARAHNMK EIKSLLSKYA SHLLEENKTL EAVELYRKAH HFLDAAKLMF
KVADKEAKKM SRPLRVKKLY VLAAQLVEDY HEQVKASQQI KAKGKKSEAT FALAGLLEED
ATSSDNRIVD SAWRGAEAYH FFLLAQRQLH AGYPENATRT ALHLREYEDV IPAVEIYSLL
ALCSAANRSF GTCSKAFIKL ESLESLSSEQ RQLYEDLALQ IFTKYPPKDS RVVEAQHSSE
GAEGKLPTCI VTGRPIQEYQ FWMCSVCKHC ALEQEISKYN CCPLCHSALV
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