ID A0A087XY66_POEFO Unreviewed; 3038 AA.
AC A0A087XY66;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Laminin, alpha 1 {ECO:0000313|Ensembl:ENSPFOP00000010719.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000010719.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000010719.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01017478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000010719; -.
DR Ensembl; ENSPFOT00000010734.2; ENSPFOP00000010719.2; ENSPFOG00000009921.2.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00940000157124; -.
DR OMA; TVRQHVH; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 14.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF409; LAMININ SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 2.
DR Pfam; PF00053; Laminin_EGF; 15.
DR Pfam; PF00054; Laminin_G_1; 3.
DR Pfam; PF02210; Laminin_G_2; 2.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 12.
DR SMART; SM00180; EGF_Lam; 14.
DR SMART; SM00281; LamB; 2.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS50027; EGF_LAM_2; 11.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 1..249
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 377..429
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 430..477
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 487..687
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 721..766
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 767..824
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 825..877
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 918..964
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 965..1010
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1011..1056
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1137..1322
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1365..1413
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1414..1468
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1469..1515
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2080..2266
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2274..2450
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2457..2643
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2685..2853
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2858..3035
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 2020..2075
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 377..389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 405..414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 448..457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 739..748
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 795..804
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 849..858
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 861..875
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 918..930
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 938..947
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 983..992
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1011..1023
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1013..1030
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1032..1041
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1384..1393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1439..1448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1469..1481
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1471..1488
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1490..1499
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2616..2643
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 3038 AA; 328527 MW; E565B7BEA919097A CRC64;
GLFPAIFNLA NNAEISSNAT CGDPEPEVYC KLVEHVPGRR IKNPHCPRCD ANSVLAKERH
PIINAIDGTN QWWQSPSIKN GRQFHWITIT LDLNQIFQVA YIIIKAANSP RPGNWILERS
LDGVTFDPWQ YYAISDSECL HRYNITPRFG PPTYRSDTEV ICTSYYSRLN PLEHGEIHTS
LINGRPGADD LTPDLLNFTS ARYIRVRLQR IRTLNADLMT LSVHDPRDVD PIVTRRYYYS
IKDISVGGMC ICYGHAQSCP LDPVTKKLKC VCEHNTCGEN CNECCPGYHQ LPWQPGTLSE
GNTCEKCNCH NKASDCFYNQ TISDLGLSLN RHGVRRGGGV CIDCQQNTIG TNCESCRDGY
YRPAEASPYS DLPCVECSCD LRGSRSSVCH KDDTEPGLSV GQCQCKDGFS GRHCDRCAFG
FRDFPACARC ECNLAGSTNS DPCSSCTCKV NVLGVHCDQC KPGFYDLQQQ NPLGCTDCFC
FGVSDICQSS DWSVTQVMHL TCAQVVLSDA VLQPSDPVQA ALGVHGNDLG IPSNASSTVA
HKHRLVWGAP RHFLGNKLVS FGGQLVFSVV YDVAPDNRDQ TLTVLSDVIM QGNGRTLRLS
PPLLLFLLPL AEQPVAMEIY PDRFVDNRTG GPVTRHDLLL VLTDLTRLYV RVHLNTSTEG
PIRLGSVSLD VASSGSGSGV RAVAVETCEC PAGYSGTSCE SCLPGFYRVG AVLFGGYCMQ
CECSSRSTHC DITGVCQGCS HNTTGPHCEL CLPGFYRDPT NGDCRLCPCP LTEPSNSFSP
TCVVEPSGQV SCDRCQPGYA GSNCERCASG FYGNPQVVGG ACVSCECNSN VNMSEAGYCD
AVTGECLRCL GNTAGKHCEA CRPGYYGDAV ITKDCKDCGC DVNGSSSSVC DITTGLNTLL
LSQLGFFGLQ SGRGCLPCGC IQSGSVSESC DQDGRCHCTE GVAGDKCDRC SRGYYGYHSR
NCTECICDHT GGNCDPDSGE CICPPNTEGD SCDRCETGYW GHDPSTGCKP CSCSAAGSSA
SRCHLLSGQC PCRDGFSGRS CDRCAPGYYG YPACSACDCD LAGTNETYCN KTLGVCECGW
TGECVCKASV SGRRCEECVS GWFALSDQNP NGCFDCFCSG LSKDCEEQGG LTRVPVGLGP
VLSLVSLSSQ QSVVSGVYQQ GGDMLLDTRQ LNSSGLAGPL YWRLPHQAEG NQLMSYGGLL
SYIITFYAED GSGLSNQEPQ VLMRGGILRK HTIFTDVVAP SNGIVTQHDI RLTEHTWKYF
NSVSQRAVTR VDFMSILSKV QDVLIKASYG TGLQRRISNV TMEAAVRAES DSSQEKARLI
ESCLCPLGYS GRSCQVCSAG FFRQPQSELP AQSLKTMTVR PCLPCRCNNH SATCDPETGD
CQDCQHHTSG RQCEVCSPGY YGNVSGSISD CSPCACPLVV NSFSPSCVSA AGGFRCTSCL
TGYEGRRCER CSPGYHGNPT VPGGLCLPCG CSGWGSLHQV CDDLTGHCQC KPGVRGQSCD
QCGERHVLHQ EQCVSCIDGC SAVLLDDLDR LNDRILSVNL SAVAMAPYHQ LVLLENRTKD
FKIRLTSRHE RSGVSELLLQ RVSSLQDEIQ VEIFYLVTLT WVPVVRSQEV FTPQQSNTSD
LIGSVLQKGV GLLNQTNDGE LTEDGAVRLE EAEVRLQRIR GVNLTAAGSA VNQELSLSEA
LLRLLQMDLM SRWTPGKDRL HALSNSLGVA MTTLQHARAP LGEAAERNSE TEKLLDAAGA
LQRHLQVSPS SRQAARQNLG SALVAVHRLM EDGQTMQKDA VSLSAQLTNR SAVELLASQL
DQLRPALRKH VEVLLVGLKT SSALENVHRA EGHAHQLQSH AHSLHRLVNG SQSPAPWALL
DDDVIQRVGS AHQEAGSGLI AASLALHLTG QSEQTLAEEG GARLNVASRV LEESWQFNAT
AEVLQANVSM VTTKLQLARD GMENCSRLLH HPIRELQQLP PGDRPSAAGS SRLAQLQAEQ
AHLGLQGVLL RLQGLWLQLQ NSSSVVEKTH ITVRETSGLM GRAQATANEV QRRLEEAEHR
TKQLLERLKP LSMLGETLSR NLSDIRELID QARRQAASIK VAVQADRNCV RSYRPPVQSS
NFNTLSLVLK TSRPNNLLFY LGSNTTVDFL AVEMHHGKVS LLWNLGSGTT QLQFPETDIA
NNRWTKINAT RFGAHAALSV HQLDSRSAPL PAVTSPSPGL SRVLDIDRNT VIHIGGMGAF
TQVALRQVDR WLHSSSFQGC LGEASLNEQN IGLWSYVSRE GQCSGCFSSP QAEETSFYFD
GSGFSMVQKS LKATSTSIVL LFKTLSPGGL LLYLASNNTR DFLSLELVEG HVRLAFDLGS
GVLVQTSNRK YNTGVWFKVT LQRNKRKGYL SVMAADQSLE KEVLEAESPG TASDLNRYDL
DPIYIGGFPS SRPIRRQVVS RAYVGCIKNM EIARSNFDLL KNAFGVRKGC VLKAVRSVSL
LSGGFVQIAP PSFGQEAEFL FTFSSNNQSG VLLAAFSDDR VNRQVRPTQY FLSLHLVSGG
VEAEVGDLGG ATRKVKVLKS GGGSFGDGSE HSVVMTVNRK SLSLQVDDVH LKSAPLMFGG
FSRLTPSSLF IGGLPPEKES RLPIRLRVSS QRFRGCIHHL VVGGALVDLS VAVRYKGAEL
NTCLLERSTA GAVLPDNPDI ESMPAGDWFV LKCVAEQEIS FLPSTAQFGS SSHSHMTFLI
NPGAFRKIVS VRLSVRSRAL DGLMLLLSDA KQMDFVVLGL RGGRVRLSAD LGKGPASVLS
ATVNDGHWHS VSAEVSRRSV SLTVDGSRPA TASIKGNHLD VDRTLFLGGL PASVNGRRIG
VSSSLPGCLR SVSLNGTMLD LSKPFSQHDV TSCFTKDQTG SYFNGSGHAE FMHDGYKVGA
DMAVSLEFRT SQSEGIFLGI SSAKVDAVGL EMVDGQVVFN VNNGAGRMAL RSTGPMLCDG
RWHHLVARKT KHGLALSVDG TQYSAANPYP QSTSAETNNP VYLGGVPASV KQNCLSVRSG
FRGCLRNLRL ARSHLNLPLH LSSAHFLSGV TPDSCPAS
//
