ID A0A087XYD1_POEFO Unreviewed; 566 AA.
AC A0A087XYD1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Mucolipin-1-like {ECO:0000313|Ensembl:ENSPFOP00000010784.1};
GN Name=MCOLN1 {ECO:0000313|Ensembl:ENSPFOP00000010784.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000010784.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000010784.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01017561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007576507.1; XM_007576445.2.
DR RefSeq; XP_016518669.1; XM_016663183.1.
DR RefSeq; XP_016518670.1; XM_016663184.1.
DR AlphaFoldDB; A0A087XYD1; -.
DR STRING; 48698.ENSPFOP00000010784; -.
DR Ensembl; ENSPFOT00000010800.2; ENSPFOP00000010784.1; ENSPFOG00000010733.2.
DR GeneID; 103154954; -.
DR KEGG; pfor:103154954; -.
DR CTD; 795916; -.
DR eggNOG; KOG3733; Eukaryota.
DR GeneTree; ENSGT00950000183036; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR GO; GO:0035675; P:neuromast hair cell development; IEA:Ensembl.
DR GO; GO:0001895; P:retina homeostasis; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF6; MUCOLIPIN-1; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 301..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..286
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 385..522
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 566 AA; 63719 MW; 371BC86E65909983 CRC64;
MASSGYTCVP DSPAEKQKLL SSKSGYGSQD VLGCASLADS QFRGQPQDED EEEEALRRKL
KYFFMSPCDK YHAKGRKPFK LGLQLLKIII VTVQLVLFGL SNQMVVTFKE ENTAAFKHLF
LKGYQDNRPQ AVHTQLELYS RIGFVVEQYM ALPQIALGRY AYVKGVGANG SALSLCQRYF
KTGTIDPVND TFDIDPHVVT DCIGLDPVPD SPVTRNADYK NFTLQFYKLI NVTVDFQLKA
INIQTIINNE IPDCYTFAIT IVFDNKAHSG KIKILLQNQA SIKECKDTNV SGHAESYARE
FFDVVVAIVC LLSLLLCGRS ILRGILLQHE YVQFFNHKLE RTVSWGDRME FINGWYILLI
ISDLFTIVGS FIKIGIESKT LSSYDVCGIL LGTSTLLVWV GVIRYFSFFQ KYNILIVTLR
AAFPSVIRFC CCVAVIYLGY CFCGWIVLGP YHVKFRSLSM VSECLFSLIN GDDMFVTFAE
MEQSGTLVWV FSQVYLYTFI SLFIYMVLSL FIALITGAYD TIMAQTREQV PETELHAFIA
QCTDTPSSGK FRGPDGSSCS FLCCCD
//
