ID A0A087XYL8_POEFO Unreviewed; 787 AA.
AC A0A087XYL8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000010871.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000010871.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR EMBL; AYCK01000700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01000701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XYL8; -.
DR STRING; 48698.ENSPFOP00000010871; -.
DR Ensembl; ENSPFOT00000010887.2; ENSPFOP00000010871.2; ENSPFOG00000010905.2.
DR eggNOG; KOG3667; Eukaryota.
DR GeneTree; ENSGT01080000257420; -.
DR OMA; FDWKNRQ; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16855; STAT5_CCD; 1.
DR CDD; cd16849; STAT5_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR046994; STAT5_CCD.
DR InterPro; IPR035858; STAT5a/5b_DBD.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF39; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 590..691
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 135..169
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 787 AA; 89385 MW; D3FC8AD5F37D3A07 CRC64;
MAMWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLAQWIES QPWDSVDLDN PGEEAKAKRL
LDNLVAELQK KAQVQGGEDG FLLKIKLGHL ASQFKSTYDR CPFELVRCIK HILQSEQRLV
QEATNASSGI GGQAMDTLSQ RHQQINQAFE ELRLATQETE NELRKLQHSQ EYFIIQYQEN
LRIQAQLSSL SSVPPAERTQ REAALQSKRA TVEAWLAREA STLQKYRLDL ADQHQKTLGL
LRKQQTLILD EELIQWKRRQ QLAGNGGPHE GGLDVLQSWC EKLADLIWQN RQQIRRCEHL
TQQLPLPGSI EELLTKLNAD ITDIISALVT STFIIEKQPP QVLKTQTKFA ATVRLLVGGK
LNVHMNPPQV KAVIVSEQQA KALLKNESTH SESSGEILNN NCVMEYHQAT GTLSAHFRNM
SLKRIKRSDR RGAESVTEEK FTILFESQFS IGGNELVFHV KTLSLPVVVI VHGSQDNNAT
ATVLWDNAFA EPGRVPFLVP DKVLWTQLCE ALDMKYKAEM HSGRGLTEDN LVFLAQKAFS
NSSNNPEDYR NMTISWAQFN RENLPGRNFT FWQWFDGVVE LMKKHLKPHW NDGAILGFVN
KQQAQDMLMS KPNGTFLLRF SDSEIGGITI AWVAENPNKQ GERLVWNLLP YTTKDFSIRS
LADRISDLNH LLFLYPDRAK DEVFAKYYTP PLCMSKPVDG YVKPQIKQVV PEFTTPNPEP
CAGVVFMDQT ASSSGSHSNN FGVYSSISDN MLDPDGDFDL EDTMDVARHV EELLRRPMAN
QWSSQQS
//
