ID A0A087XZ62_POEFO Unreviewed; 2609 AA.
AC A0A087XZ62;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Filamin B {ECO:0000313|Ensembl:ENSPFOP00000011065.2};
GN Name=FLNB {ECO:0000313|Ensembl:ENSPFOP00000011065.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000011065.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000011065.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01017035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000011065; -.
DR Ensembl; ENSPFOT00000011081.2; ENSPFOP00000011065.2; ENSPFOG00000010118.2.
DR eggNOG; KOG0518; Eukaryota.
DR GeneTree; ENSGT00940000156286; -.
DR OMA; RAVPCKV; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 138..241
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 248..345
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 347..445
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 446..543
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 544..636
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 640..736
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 737..840
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 841..934
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 935..1031
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1032..1124
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1125..1223
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1224..1323
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1324..1416
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1417..1512
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1513..1608
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1609..1704
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1763..1821
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1821..1913
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1911..1999
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2002..2094
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2091..2190
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2193..2285
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2287..2380
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2384..2476
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2514..2608
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 244..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2497..2522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2609 AA; 277710 MW; 571520AD68E54DBD CRC64;
MPATEKDLAE DAPWKKIQQN TFTRWINEHL KCVNKRIVDL QLDLGDGLRL IALLEVLSQK
KMYRKYHPRP NFRQMKLENV SVALEFLERE NIKLVSIDSK AIVDGNLKLI LGLIWTLILH
YSISMPAWEG EDEEAETKTP KQRLLGWIQH KVPDLPITNF SQDWRNGRAL GALVDSCAPG
LCPDWETWDP VKPVENATEA MQLADDWLGI PQVIAPEEII DPSVDEQSVM TYLSQFPKAK
LKPGAPLKPK LNPKKARAYG PGIEPTGNRV LRPAVFTVDT FSAGQGQVMA YLDHPDGTRE
ELKVEPNEGK KTYSVTYVPQ VMGPHKVTVL FAGQQIPKSP FEVNVDKALG DASKVTVKGP
GIEPVGNIAN KPTYFDIYTA GAGTGDVTAM IRDPQGRQNS VEVMMEDKGD SVYRCTYRPT
QAGPHAITVT FGGVGVPKSP FAVDVGPACM PGACRATGRG LQPAGMRVKQ VGDFKVDTRN
AGSGELKVLI KDSKGNEEPV KQVLSQDGVF CYEYYPRSPG KYTVSITWGG QHIPKSSPFD
VAISPEAGPQ QIRAWGPGLK GGIVGKPATF VVESIGTDVG VLGFAIEGPS QAKIECEDKN
DGSCDVRYWP TEAGEYAVHV TCDEEDIELS PFMAHIVPDN NTSHPEKVRA YGPGLEPTGC
QVDQLAEFTV EAEDAGKGPL KITAQDAEGL PVEVKVRSKG EGLYQCCYTP SSSLKHTVSV
SWAGVSVPNS PFRVNVGKGS HPNKVKVFGP GVERSGLKAN EPTHFTVDCS GAGDGRDVSV
GIKWDSSTDS DQEADVDFDI IPNANDTFTV KYVPPAAGRL TVKVMFTDQE VPHSPFMVKV
EPSHDASKVK AKGPGLAPTG VESGKPTHFT VVTKGAGKAP LDVTFSSSVK DFDIIDNYDY
SHTVKYTPVQ QGEMTIVVTF GGDPISSSPF TVGVAAPLDL SKISVDNLDG RVEVNEEQQF
MVDTQGAGGQ GQLEVEVLSP SQRAVPCKVE PQPGRAAVSS VRYTPTEEGV YAVNVSYDGH
PVPGSPFPVE AQLPPDPSKV KAFGPGLKGG LVGDPAEFTI DTKGAGTGGL GLTVEGPTEA
KIECSDNGDG TCSVSYLPTE PGDYLVNILF ENVHIPGSPF RADIQMPFDP SKVVASGSGL
KKAKVGEISV LNVDCSRAGP GQLSLDAAPE SGPGSGMKAK TEVVDNQDGT YMVTYVPLTS
GMYTLMLKYG GKSVPGFPAK VMVDPAVDTS KVKVFGPGVE GQAVFREATT DFTVDARPLT
RRGGEHVKAE VKNPSGALTE CVVTDQADGT YSVEYTPFEN GVHSVSVLYD DTPVPKSPFR
VSVMEGCDPS RVVATGPGLQ QALTDQNNTF NIITRGAGIG GLGITVEGPS ESKMSCKDNK
DGSCSVEYVP LTPGLYDINI TYGGEHIPGS PFKVPVKAVV DSSKVKVSGP GVASGVRANI
PQSFSVDCRK AGEAPLAVAV TGPKGLAEPV EVTDNGDGTH GVLYTPTVEG PYSICVKYAD
EDVPFSPFKF RVLPTHDASK VRASGPGLTS GVPASFPVQF NIDARDAGQG QLSVLITDQD
GKPKQPSILD NDDGTYTVSY VPDRTGRYTI VIKYGGDDIP ASPYRVRATA TGDASKCTVT
GPGVGPTVAI GEELGLVVNA KAAGKGKVSC VVVQPDGSEV EAEVMENEDG TFDIYYTTPA
PGNYAIYVRF GGENIPRSPF KVMATDEVPI SQQQMAQQRQ AGPPSAGFQP WVTSENYQPI
SSSVNGSGFR PFDMIIPFAF RPGEITGEVL MPSGKSAQPL IADNGNGTVI VQYAPTEAGL
HEMHIKYNGT HIPESPLQFY VNHSSSPNVT AFGPGLSYGV ANKVATFTVC TDDASEGGLD
LAIEGPSKAE ISCVDNKNGT CTVSYLPTLP GDYNILVKYN EDHIEGSPFT ARITEDNQRR
SQVKLGSAAD FFLDINETDL SVLTASIRAP SGRDEPCLLK RMANNHTGIS FIPREVGEHQ
VSILKNGRHV PNSPITINVV QSEIGDAGRV KTHGDGLVQA TTFTNSSFVV DTREAGYGGL
ALAIEGPSKV DIQTKDVEDG TCEVSYCPTE PGNYIVSIRF AEEHVPGSPF RVRVTGEGRI
RESITCRQKA ASVASIGSMC DLNLKIPAMD MQDITAEVTS PSGTSRPAEL VSMGNDTYCV
RFVPTEMGVH SVCVKYRGVH VPGSPFQFTV GPLGEGGAGK VTAGGPGLEG ALAGEPAEFS
IWTREAGAGG LSVAVEGPSR AEISFDDRKD GSCGISYVAQ EPGDYEISVK FNEQHIPDSP
YLVPVVAPVN DARRLTVAGL QESGLKANHP ASFAVRLNGA QGKLEAKVHS PSGALEECVV
TELEKDKYAI RFIPRENGVH TIDVKFNGSH IPGSPFQVRV GEPGQSGEPG LVSAYGSGLE
RGTTGTQSEF IINNTKAGPG ALAVTIEGPS KVKMDCQEIP EGYKVHYTPM APGTYMISVK
YGGPNHITGS PFKARVTGNR LVNVTNANEM STLTLDPTQR TAGSGFAQSA MPRPGDSDAS
KVLSRGPGLS KAFVGQKSNF SVDCSKAGKN MLLVGVYGPQ VPCEEVLVKH LGNLQYNVSY
VLKERGGYIL VVKWGDDHIP GSPFNVTVP
//
