ID A0A087XZT3_POEFO Unreviewed; 788 AA.
AC A0A087XZT3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Leucine rich repeat and fibronectin type III domain containing 2 {ECO:0000313|Ensembl:ENSPFOP00000011286.1};
GN Name=LRFN2 {ECO:0000313|Ensembl:ENSPFOP00000011286.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000011286.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000011286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01001329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007575548.1; XM_007575486.2.
DR RefSeq; XP_016517876.1; XM_016662390.1.
DR RefSeq; XP_016517885.1; XM_016662399.1.
DR AlphaFoldDB; A0A087XZT3; -.
DR STRING; 48698.ENSPFOP00000011286; -.
DR Ensembl; ENSPFOT00000011302.1; ENSPFOP00000011286.1; ENSPFOG00000011311.1.
DR GeneID; 103154267; -.
DR KEGG; pfor:103154267; -.
DR CTD; 57497; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000156417; -.
DR OMA; ELMDFSA; -.
DR OrthoDB; 2942402at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR CDD; cd05764; IgI_SALM5_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF6; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..788
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001833786"
FT TRANSMEM 521..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 289..375
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 413..510
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 390..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 86522 MW; 98A1220BAB0E6FAE CRC64;
MDKVVICLLI LGAAMTMVHA CPKYCVCQNL SESLGTLCPS KGLLFVPPDI DRRTVELRLG
GNFILKVTTQ DFANMTGLVD LTLSRNTISS IQPFSFIDLE TLRSLHLDSN RLTELGADDL
RGLINLQHLI LNNNQLNQIS DSAFDDLLLT LEDLDLSYNN LRSVPWEAIR KMVNLHQMSL
DHNLIAFIAE GTFTDLEKLA RLDLTSNRLQ KLPPDPIFAR SQSSMVMSTP YAPPLSLSFG
GNPLHCNCEV LWLRRLDRED DMETCASPAS LKGRYFWSVR EEEFVCEPPL ITQHTHKLLV
LEGQTASLRC KAVGDPMPTV HWVAPDDRLI GNSSRATVYE NGTLDIAVTT SKDYGIFTCI
AANAAGESTA SIELSIIQLP HITNSTNRTT LPKSGLSDIT SSTKIGKGEP KPPPEKVVSV
SEVTAISALV KWTVSKSTPK VKMFQLQYNC SDDEVLIYRM IPRTHRAFVV TNLVPGMQYD
LCVLAIWDDT ATTLTATNIV GCIQFVTTED YPQCQSLHSG FMGGTMILVI GGIIVATLLV
FIIILMVRYK VTSGIQTNKL PTVSNTYSQT NGGVNRFNGA PPQVKSTVVV MREEMVEFKC
GSLQSSLSSS SSSSNSLDSQ TGRGAGYNAQ SSECSNLPST KFRRHVHGTK ARQNLDQLLG
AFTSLELRGA AKDHQGTSVS SSSAVANPMT TVAVAPPSDK EPLLGRAEST TMLGRLLGFQ
HEDKPKRSHS FDMGHVGAVQ CRSSQPRRIS NIWTKRSLSV NGMLLQYDDS EDEKPTFESS
EWVMESTV
//
