ID A0A087Y0F1_POEFO Unreviewed; 1446 AA.
AC A0A087Y0F1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Nuclear receptor binding SET domain protein 3 {ECO:0000313|Ensembl:ENSPFOP00000011504.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000011504.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000011504.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AYCK01009758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPFOT00000011520.2; ENSPFOP00000011504.2; ENSPFOG00000011218.2.
DR GeneTree; ENSGT00940000155355; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15565; PHD2_NSD; 1.
DR CDD; cd15661; PHD5_NSD3; 1.
DR CDD; cd20163; PWWP_NSD3_rpt1; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR041306; C5HCH.
DR InterPro; IPR047527; PHD5_NSD3.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR047451; PWWP_NSD3_rpt1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22884:SF473; HISTONE-LYSINE N-METHYLTRANSFERASE NSD3; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF17982; C5HCH; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00855; PWWP; 2.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00249; PHD; 4.
DR SMART; SM00293; PWWP; 2.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50812; PWWP; 2.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 280..343
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 698..745
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 965..1030
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 1102..1152
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1154..1271
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1278..1294
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 1330..1377
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 24..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1063..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1420..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..254
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1079
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1446 AA; 160984 MW; 9947A202043C00C1 CRC64;
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ DGSCDTGSDP GEDSGPSYDA ALDAEFSYPP
SASEDMPQVP NGYPPGLGLY EPQAKFSMYS QFPNGSANGY GAIRSYGDHG LLPGEGTVLR
GPGLHERPLS PVSPPLSVHP ALAPSNTPGG GVLKKTSSPE IKLKIIKTYQ NGKELFESAL
CGDLLQELQV TGQTQRRHER KKEKRKKSAR LQLQAQQSVE RSQEQTASTA QTEESVQPQP
REPPPLPPSD PPPAQAEKTQ RTVIKTEPKT PKAKSEEFVI GDLVWSKVGT YPWWPCMVSS
DPQMKVHTRI NTRGHREYHV QFFGSVAERA WIHEKRIVTY QGKQQFDELQ AETLRKATNP
VERQKLLKPI PQRERTQWEV GVGHAEDAFL MTRQERIDNY TFIYVDPDPE EAPPTKKPSI
RAEKRSRRSS GSVGKKEDVG VKSPDREQPP RRQLPRRQCS ISNTEDSPPP VVRPWKTAAA
RKLLPLSITM KRLNVEITKC DWPLLQKNIT PSQDSRAKPE PSPEEEEEEG DEGEEESDER
RGSPASRRSE SANRQNSSPG SPSSSPQGSQ ERKPQRRSVR SRSESERGAD PIPKKKTKKE
QAEMAPETTL KTGSQKGASE ISDACKPLKK RSRASTDVEM ASSQYRDTSD SDSRGLNDPQ
GLFGKSLDSP AAADADASDT QSVDSGLSRQ DSGTGQRDTV CQICEAYGEG LVVCEGDCSR
QFHLECLGLS SPPEGRFTCT ECRNGNHPCF SCKSVDPEVT RCSVSGCGCF YHEDCVRKLP
GTTSGSGGGF CCPQHSCSTC CLERDLQRAS KGRLIRCIRC PLAYHPSDGC LAAGSVILTH
HIMICSNHGS AKKNGLLSSP VNVGWCFLCA RGLLVQDLTD TILSSYAYKS HYLLTESNRA
ELKLPMIPSP SSATKKNVGK DPNVGGKLLC CDSCPASFHP ECLEMEMPEG AWSCSDCRAG
KKPHYKQIVW VKLGNYRLLK WWPAEICNPR LVPSNIQSLR HDIGDFPVFF FGSHDYYWIN
QGRVFPYVEN DKNFVTGQIN INKTFKKALE EAARRFQELK AQRESREALE QERNSRKPPP
YKIIKQSNKP VGKVQMHVAD LSEIPRCNCK PTEEHPCSLD SQCLNRMLQY ECHPQVCPAG
DRCENQCFSK RLYAETEVVK TEGCGWGLRT NQTLRKGDFV TEYVGEVIDS EECQQRIKRA
HENHVTNFYM LTLTKDRVID AGPKGNSSRF MNHSCSPNCE TQKWTVNGDV RIGLFTLCNI
EAGTELTFNY NLHCVGNRRM SCHCGSDNCS GFLGVQPTSA VVMEKEEKAK NAKLKPKKRK
LRPEGKHTHE YVCFCCGEGG ELVMCDRKDC PKAYHLLCLN LTKPPYGRWE CPWHDCSVCG
ASASSLCDFC PRSFCRDHEA GALTASALDD RLCCSNHDPL SPLGSDSTQP RRFDRSPVRV
KEESKE
//
