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Database: UniProt
Entry: A0A087Y1H2_POEFO
LinkDB: A0A087Y1H2_POEFO
Original site: A0A087Y1H2_POEFO 
ID   A0A087Y1H2_POEFO        Unreviewed;      1268 AA.
AC   A0A087Y1H2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE            EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE   AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000011875.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000011875.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC         isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC         Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC         ChEBI:CHEBI:456215; EC=6.1.1.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00000114};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR   EMBL; AYCK01000361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007549323.1; XM_007549261.2.
DR   AlphaFoldDB; A0A087Y1H2; -.
DR   STRING; 48698.ENSPFOP00000011875; -.
DR   Ensembl; ENSPFOT00000011892.2; ENSPFOP00000011875.2; ENSPFOG00000011883.2.
DR   GeneID; 103136144; -.
DR   KEGG; pfor:103136144; -.
DR   CTD; 3376; -.
DR   eggNOG; KOG0434; Eukaryota.
DR   GeneTree; ENSGT00550000074921; -.
DR   OMA; EIIVIHK; -.
DR   OrthoDB; 656at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR   CDD; cd00818; IleRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   HAMAP; MF_02003; Ile_tRNA_synth_type2; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR033709; Anticodon_Ile_ABEc.
DR   InterPro; IPR002301; Ile-tRNA-ligase.
DR   InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00392; ileS; 1.
DR   PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF19302; DUF5915; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00984; TRNASYNTHILE.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT   DOMAIN          17..638
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          693..849
FT                   /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT                   anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
SQ   SEQUENCE   1268 AA;  145395 MW;  986589E6538C6694 CRC64;
     MVEPVPESIN FPSEEEKILQ FWQERDCFQE CLKQSKNRPR YTFYDGPPFA TGLPHYGHIL
     AGTIKDIVTR FAHQSGFHVD RRFGWDCHGL PVEYEIDKTL GIKGPEDVAK MGIAEYNKQC
     RNIVMRYSNE WEATVRRMGR WIDFKNDYKT LYPWFMETVW WVFKQLYDKG LVYRGVKVMP
     FSTACNTPLS NFESHQNYKD VQDPSVIVSF PLVESENVSL IAWTTTPWTL PSNLALCVNP
     EFLYVQVKEN TTERTYIMME ARLGALFKSE GEYTILNKFP GKDLKGKKYK PLFHYFSKCA
     EKGAFQVVTD NYVKEEEGTG VVHQAPYFGA DDYRVCTEYN IIQRDQTPIC PVDASGCFTS
     EVTDFAGQYV KDADKNIIKL LKEKGRLVNA STFKHNYPFC WRSDTPLIYK AVPSWFVRVE
     HMVDKLLDCN GKCYWVPEFV REKRFGNWLR DARDWAISRN RYWGTPIPLW VSDDFEEVVC
     VGSMAELEEV TGVKVTDLHR ENIDSLTIPS RCGKGVLRRI TEVFDCWFES GSMPYAQVHY
     PFENRKEFED TFPADFIAEG IDQTRGWFYT LLVLSTALFG KPPFKNVIVN GLVLASDGQK
     MSKRKKNYPD PGVIVQNYGA DALRLYLINS PVVRAENLRF KEEGVRDVLK DVFLPWYNAY
     RFLVQNVQRL QKEEEIQFLY NENTVKQSDN IMDKWIQSFT QSLIQFFKAE MDAYRLYTVV
     PRLVKFVDML TNWYVRTNRR RLKGESGTED CLWALETLFS VLFSMCRLMA PFTPFITEMM
     YQNLRHLIDP ASVEEKDSNS IHYLMLPQVR DNLIDKRIES AVSQMQSVIE LGRVIRDRKT
     LPVKYPLKEV VVIHQDPEAL KDIQSLEKYI LEELNVRQLT LSTEKDKYGI RLRAEPDHMV
     LGKRLKGAFK AVTASIKELT SEQLEAFQKT GSIVVDGHEL HEEDLRLMYT FDQTSDSAAQ
     YEAHSDAQVL VLLDVTPDQS MVDEGVAREV INRIQKLRKK AHLVPSDDIL VYYRCQPEGE
     YLGSVIEAHT DFILATTKAP LLPFPVPKTA SVIIEEKTQL KGSDLEFTIV KGSSLSQTKP
     NGPVCAYINL RVKVDNKEQE GVVLLENPRG DNRLDLDKLR KVCSSIFGIN NTQLRFFSDQ
     SELTSSADLQ AYSGKTLLVT SGPSPPGAVP TADTLLCPYV NLLLWNAVPA ECQAGDAGTL
     LLVNPVGRNE LDHSGLLSEA AKLFGLRGRR IKLYLDHHLT SELPAESSVK SLHTKTLFVR
     VFPTTAEA
//
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