ID A0A087Y1P6_POEFO Unreviewed; 1873 AA.
AC A0A087Y1P6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Bromodomain adjacent to zinc finger domain, 2A {ECO:0000313|Ensembl:ENSPFOP00000011949.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000011949.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000011949.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR EMBL; AYCK01011345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000011949; -.
DR Ensembl; ENSPFOT00000011966.1; ENSPFOP00000011949.1; ENSPFOG00000011764.1.
DR eggNOG; KOG1245; Eukaryota.
DR GeneTree; ENSGT00940000159490; -.
DR OMA; IEDSTHF; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15545; PHD_BAZ2A_like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF5; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00384; AT_hook; 4.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 544..615
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 845..910
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1645..1695
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1777..1847
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 28..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1703..1757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 773..815
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 28..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1164
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1305..1348
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1371
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1703..1735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1739..1753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1873 AA; 208455 MW; A2F2F4716A1ED615 CRC64;
MDSNNHFNYG TSTNSGLKLS SGDSLYTNGS SMSFPQQGKN LNGEMNVNGV TTVHGSNVSG
SHPPSAPYPH MSGHHQGGVG YEYLYGPGMG SSSGQGVHQK QPAPGITQSQ SQHHFQSHSQ
YQLNGGVEAS HQPPIAGQTN VPLTGNSQYW NRSNPTQQQM SYNSPSMYGS FHSQSHPMMT
NGMPFYQPPQ QQLPQQSQSQ TRIMPPAAQN FTPPRGSPQH HSLGRGSSSS PLPVGMSPTP
VVSPPIQDCG SPKGLSRDRS PHTSSAVCRR PKTCLCLKDP GNLVKLQILK HQIHSSESIS
VGTVSSGPPA SSSSEFLIDQ TKAVGNSDSP NLAASSLTSE RHAPDLVRTE SHVAAVETKK
PEVCQYKSPT DPPGKSLQAS EGNLQNASDL EKHEVKSSIL SGAADSPVAS TPIGKPPHLK
STSWTPRPAL SRASLLRLTA PEKAASRWRT PEMTPWSRPD ILCCIYKEVD PITAAINAVL
ANASALSTVV QKPKKMKRVR KQDQDGSAAG AQKRDAETTA DDGDENDDSS TAGNETGESN
RRRVASEEQV QFPLQHGWKR EIRVKKMDNR MKGETWYYTP CGRRMKQFPE IIKYLKKHSD
GVVSREHFSF SPRMPVGDFY EERETSEGVK WVLLANEEVP SMIMAITGRR GRPPNPDKEK
PRRIGALKAG QARRPGRPPK FNAVDLLSKV DAKLLNRLEA KGERMFVVLA PLCKSFKGEQ
TSHRGGEGEA RMKRREDLKI KKMKEEKKKA KPSDEKVVQS NRAASARSKA KALAKAQAEA
EAAAQAALAA KRAAERRAQA QRRLEERKRQ QLIAEELKKP TEDMCLTDHK PLPELSRVPG
LVLSGTAFAH CLAVVEFLHG YGKIIGINVP KDIPSLSTLQ EGLLGLGDSQ GEVQDLLIKL
VESALHDPGL PSYYQSVKIL GEKLVDLELT RNTVSEVLRI YLESHGYETE VCNTLRTKTF
HILPPDTKAA ILGFLVEELN SSNIVMSDID NTLENMATYR KNKWIIERKL RKLKPVLARR
TGRSEEELCF EERRRSARVA EEENFSLEES GLVLERGSRR ARKEESESPT TASIPELERQ
IDKLTKRQAF FRKKLLQSSH SMRVVMLGQD RYRRRYLALP HLGGVLVEGP EELLKVPVTF
LKKEPKVEEI PVPTSPPAPA SPSATPSQPQ TASVEDDPLP GTASLMSTQR GRGRPRKIKP
EVELHLRTAK IRRRRRSSVR SVGEEGPGSP NSGLLDLTQA AFKSWLSQSQ DVMTNGGGPG
PAGDAPEGGR SEESIKEMAE KHGQWFNLLP KQPCDDNSLT EPQTPASPGS PPKLLPQIPS
ALPALAPPTA SPPPPAAIAS PPAAPVTPGR PARRRRRGSS PARRGPRGAA AKRRGRPPNA
VFQELEQQYF TQLVVKPIPA SMVRGWWWIK DPEELYHTLQ ALHPRGIREK VLHKHLAKHM
ESLAEMCTKP INDPLFELKT EDKDVLLEAL QQPWQVQEKA MEVDVSALQW VEDLEQRVIA
ADLHLKPYTI PDSDSTRDDL QYYEHDVDPR DDWIVRTKKE WSGLPRIATH PLDLAVLRLA
NLERNIERRY LKEPLWNPSE VMRLAPLTPT PGEELSLDVF SLESEITSRL RTWRQALDRC
RSAPQLCLCV FQLEKAIAWE RSVTKVTCQV CRKGDNDECL LLCDGCDRGC HMYCLKPKIT
QVPEGDWFCP TCVPKKMEGE LQSLSKKRTR TKKRRYEEDS SEDETTKRRS GGMTTRHKEA
PVPSSSSSTR YSGERRRITT RNQPDLTFCE IILMEMEAHA DAWPFLEPVN PRLVPGYRRI
IKNPMDFLTM RERLLQGAYC SCDEFAADAQ LVFNNCELFN EDTSEVGMAG HSMRRFFESR
WAEFYSNKDK SNL
//
