ID A0A087Y3G2_POEFO Unreviewed; 349 AA.
AC A0A087Y3G2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000012565.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000012565.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR EMBL; AYCK01027046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01027047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01027048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007544458.1; XM_007544396.2.
DR AlphaFoldDB; A0A087Y3G2; -.
DR STRING; 48698.ENSPFOP00000012565; -.
DR Ensembl; ENSPFOT00000012582.1; ENSPFOP00000012565.2; ENSPFOG00000012578.1.
DR GeneID; 103132581; -.
DR KEGG; pfor:103132581; -.
DR eggNOG; KOG3704; Eukaryota.
DR GeneTree; ENSGT00940000165237; -.
DR OMA; EFPQAII; -.
DR OrthoDB; 10019at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR PANTHER; PTHR10605:SF75; SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transferase {ECO:0000256|RuleBase:RU361155};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..332
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 106
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 106..110
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 187
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 195
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 312..316
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 295..307
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 349 AA; 39653 MW; 8939B62B69DD641F CRC64;
MGCSRWRAAL NFGHLKAQSR LPVFLTMILL FTYLCYCLSS RCDALPRPVF SSGAPEGGRL
LGSAVPLLRH RLADSAGGMR PLDNISIFNN FGSKKFPQAI IIGVKKGGTR ALLEFLRVHP
DVRAVGTEPH FFDRCYDKGL GWYRSLMPRT LEGQITMEKT PSYFITKEAP RRVHALSRHT
KLIVVVRDPV TRAISDYTQT LSKSPGLPSF QNLAFRNDSA TLIDTSWSAV RIGIYAKHLE
NWLRYFPLSR FLFVSGERLV TDPAGEMGRV QDFLGLKRVV TDKHFYFNQT KGFPCLKKPE
GSSRPRCLGK SKGRPHPQIP TEVLLRLRDF YRPFNLKFYQ MTGQDFGWS
//
