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Database: UniProt
Entry: A0A087Y437_POEFO
LinkDB: A0A087Y437_POEFO
Original site: A0A087Y437_POEFO 
ID   A0A087Y437_POEFO        Unreviewed;      4867 AA.
AC   A0A087Y437;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSPFOP00000012790};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSPFOP00000012790};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000012790, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000012790, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000012790};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000012790}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AYCK01003405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01003406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01003407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01003408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01003409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01003410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000012807; ENSPFOP00000012790; ENSPFOG00000011238.
DR   GeneTree; ENSGT00940000155507; -.
DR   OMA; PLLNEYC; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4182   4201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4409   4429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4476   4494       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4619   4644       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4667   4689       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4748   4771       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    154       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    206       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    331       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      339    396       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      592    790       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1008   1203       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1249   1461       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4867 AA;  552018 MW;  FA2B5AF8018B47B8 CRC64;
     MFVFGLGKPR IIAFCRNDDE VVLQCVACIQ KENHKFCLAA EGLGNRLCYL EPTSEAKYVP
     PDLCICTFVL EQSLSVRALQ EMLAKSGQNS EGAAHSGGHK TLLYGHAILL RHSFSSMYLA
     CLKTSRSQTD KLSFDVGLQE DSTGEACWWT IHPASKQRSE GEKVRIGDDL ILVSVSSERY
     LHLSISNGNI QVDASFMQTL WNVHPICSGS NIEEGYLLGG HVMRLFHGHD EVVSIPGSDQ
     SEEQQRIVNY ETGKAGAKAR SLWRLEPLRI SWSGSHIRWG QPFRLRHLTT GHYLALTEDR
     GLVLQDRERS DTISTAFCFR ASKEKLEQSP KRDIEGMGVA EIKYGDSVCF IMHVATGLWL
     SYQAPDVKST RLGPLKRRAC LHSEGHMDDG LTLQRCQHEE SRAARIIRNT TLLFNRFISV
     KNRTLSALPV EEVLQTLNDL ITYFQLPDVE LEHEERQIKL RSLKNRQNLF KQEGMLTLVS
     NCIDRLNVYN SAAHFGECAG SEAGAAWKDI LNLLYELLAA LIRGNRNNCT QFSNNLDWLV
     SKLERLESSS GILEVLHCIL IESPEALNII QKGHIKSIIS LLYKHGRNHK ILDVLCSLCV
     CNGVAVRTNQ NLICDHLLPK RDLLLQTQLV NDVQSMRPNI FLGVSEGSAQ YKKWYYELMI
     DQVDHFVTSE PSHLRVGWAN TKGYAPYPGG GEGWGGNGVG DDLYSFGFDG LHLWSGRIPR
     AVASLNQHIL TSEDVVSCCL DLGAPSISFR INGQPVQGMF ENFNTDGLFF PVVSFSAGVK
     VRFLLGGRHG DFKFLPPSSY APCYEALLPK EKMKVEPVKE YKRDVEGVRD LLGTTQFTSQ
     ASFIPTPVET SQVVMPPHLE KVRDKLAENI HELWGMNKIE LGWTYGKIRD DNKRQHPCLV
     DFSKLPETEK NYNLQMSTET LNQRTLLALG CRIVQVNPNA EDSLKKIKLP KNYMMSNSYK
     PSPLDLSDIK LTPGQELLVD KLAENAHNVW AKDRIKQGWT YGIQQDLKSK RNPRLVPYVL
     LDERTKKSNR DSLREAIRTM IGYGYNIEPS DQEGGQVAER VSVDKVRFFR VERTYAVKTG
     KWYFEFEAVT GGDMRVGWAR PGCKPDVELG TDKLAFVFDG YRGHCLNIGS RLFGRCWHAG
     DVVGCMINME DKSMIFTLNG EILITTKGSE LCFTDFETED GFIPVCSLGL AQVGRMNLGK
     DASTFKYYTT CGLQEGFEPF AVNMNREVTM WFSKRLPTFV NVPKDHNHIA VTRIDGTIDS
     PPCLKVTHKT FGTQNSNADM VFCRLSMPVE FHSFFKQSPT VDINGIHEED LLKDIVLHMY
     QQYYHSVRIF AGQDPSGVWV GWVTPDYHYY SNNFNLSKNR TVTVTLGDER GRVHNSVKRS
     NCYMVWGGDM TSGAHASSRS NVDLDIGCLI DLSTGMVTFT VNGKELSTSY QVEPNTKLFP
     AVFVRPTSPN LFQFELAKIK NAMPLSSAIF KSEHKNPVPQ CPPRLDVQTI NAVLWSRMPN
     IFLKVETARV NERHGWVVQC VEPLQMLAVH IPEENRCVDI MELSEQEDMR KFHYHTLKLY
     CALCALGNTR VAHALCSHLD QSQLLYTIDN QYLSGMLREG FYNVLISIHL ETAKEARLMM
     KDEFIIPVTA ETRSIRLFSS ASKKHSPPGV GLSTSLKPRL NFTPPCFIST KRDYLYSPQI
     PLDALKEKAI SMLTEAVQGG GHHIRDPVGG GVEYQFVPIL KLISTLLTMG VLGSEDVQKI
     LLLIDPNVFK DTREEGVPGP TDKEGLTGTE GKAVEAGEEE AAEEAKQPMK GLLEKRLPEP
     VKRLMCELLH YFCDCELKHR IEAIVSFSDS FVSKLQYNQK FRYNELMLAL NMSAAVTAKK
     TKEFRSPPQE QINMLLTFSM GDDCPCPSEI QEELYDFHNQ LQLHCGIPME EDEDEKDTSI
     KGRLLMLVNK IKSQSYKAQE PTEKKQAAPS NLKELISQTM VSWAQECHIQ DPKLVRKMFS
     LLRRQYDSIG ELLRAMRKTY TISAASVQDT IHLLASLGQI RSLLSVRMGK EEEKLMIDGL
     SDIMNNKVFY QHPNLMRILG MHETVMEVMV NVLGGDKSQE IAFPKMVASC CRFLCYFCRI
     SRQNQKAMFD HLSYLLENSS VGLASPAMRG STPLDVAASS VMDNNGLALA LEEPDLDKVV
     TYLAGCGLQS CPMLLAKGYP DIGWNPIEGE RYLSFLRFAV FVNGESVEEN SSVVVKLLIR
     RPECFGPALR GEGGNGLLAA MKEAIKISET PALDLPGSVH RVSSDLSADG DDEEEVVHMG
     NAIMSFYSAL IDLLGRCAPE MHLINKGKGE ALRIRAILRS LVPTEDLVGI ISIPLKTPIL
     NKDGSMTEPD MSASFCPDHK APMVLFLDRV YGIEDQSFLL HLLEVGFLPD LRTATTLDTE
     GLCTTETALA MNRYIGSAML PLLTRCAPLF AGTEHYATLI DSTLHTIYRL SKGRSLTKAQ
     RDAIEECLLS ICKHLRPSML QQLLHRLVFD VPLLTEYCKM PLRLLTNHYE QNWKYYCLPS
     GWGSFGTASE DELLLTKRIF WGVFDSLSQR KYDPELFKMA MPCLSAIAGA LPPDYVDASI
     CTAVEKPVSV DAQGNFDPKP INTANIVLPE KLEHLTNKYA EHCHEKWSAE KVLLGWKYGD
     GVDEKAKTHP QLRIYKALTE KEKEIYRLPI RDSLKCMLAM GWSIDRTKDG ESMSLQRENE
     KMRKISQASQ ANGFNPSPVD TSNVTLSREL QGMVEVMAEN YHNIWAKKKK SDLGSRGGGT
     HPLLVPYDTL TAKEKARNRE KALDLFRFLQ INGYSITRGL KDLEQDSSSM EKRFAYKFLK
     KLLKYVDSAQ DFIAHLESMA ASGKTDRSPH EQEIKFFAKV LLPLIDQYFK NHSLYFLSSP
     NKNLSCSGYA SNKEKEMVTS LFCKLAALVR HRISLFGSDS TTMVSCLHIL AHTLDTRTVM
     KSGSEQVRVG LRTFFENAAE DLEKTFENLK LGKFTHSRSQ MKGVSQNINY TTVALLPILT
     ALFEHITQHH FGVDLLLDDV QVSCYRILTS LFALGTGKNI YVERQLPALG QCLATLAGAM
     PVAFLEPKLN THNPCSVFNT KSARDRAVLG IRESVEEMCP GMPRLDGLMK DINDMAESGA
     RYTEMPHVIE VVLPMLCNYL SYWWERGPEN QAASGGSSYC TTVTSEHLSL ILGNILKILN
     NNLGIDEASW MKRIAVYVQP IISKARADLL KSHFLPTLEK LKKKTVKVVA EEELLKADSK
     GDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRLNKS RWLKEPDSDS NELFRMVAEI
     FILWCKSHNF KREEQNFVVQ NEINNLSFLT GDNKTKMSKS FKEKSGGQDQ ERKHKKRRGE
     FYSIQTSLIV AALKKMLPIG LNMCTPGDQE LISLAKTRYL MKDTDEEVKD HIHQNLHLRE
     KSEDPAVRWQ LNLYKDIVMR IESPPDPERV VDRIQRISAA IFNLEQVEQP LRSKKCVWQK
     LLSKQRKRAV VACFRMAPLY NLPRHRSINL FLLAYQSIWI ETEEYSFEEK LVQDLAKTQP
     KVEEEEEEEV RKQPDPLHQL ILHFSHNALT ECSSLEEDPL YIAYADMMAK SCAEGEEEEE
     GKEKTFEEKE MEKQKMLYQQ ARLHDRGAAE MVLQMISASK GRLGATVTFT LKLGISILNG
     GNILVQQKML DYLKEKRDVG FFKSLSGLMM SCSVLDLNAF ERQNKAEGLG MVTEEGSINV
     SERGSKVLQN DEFTKDLFRF LQLLCEGHNN DFQNFLRTQT GNTTTVNIII STVDYLLRLQ
     ESISDFYWYY SGKDVIDEAG QRNFSKALSV AKQVFNSLTE YIQGPCIGNQ QSLAHSRLWD
     AVVGFLHVFA NMQMKLSQDS SQIELLKELL DLQQDMIVMM LSLLEGNVVN GTIGKQMVDT
     LVESSSNVEM ILKFFDMFLK LKDLTTSDSF REYDSESKGV ISKKDFQKSM ENQKQYSQSE
     IEFLLSCAEA DENDMFSYKQ FVERFHEPAK DIGFNVAVLL TNLSEHMPHD ARLSTFLNLA
     ESVLSYFEPF LGRIEIMGGA KRIERVYFEI SESSRTQWEK PQVKESKRQF IFDVVNEGGE
     SEKMELFVNF CEDTIFEMQL ASQISEPDPV ERSDEDEDES QNVVENQDEK EEENVMMESS
     SAFTIACISM RKNLCHFRQL LTLKSMRRQY RRFRKMSVRE MVKGFFSFFW MIITGLFHFI
     YSLVWGFFHI LWTTMFGGGL VEGAKNMKVT DILGNMPDPT QFGIHGDVLE TEKMEANDAS
     ALEEMGQMAQ GDAAETDLMA ELLNIQPRRE GKHGTEPGLG DVSEVVVGDA PSIASAVRQK
     KAQMAAKKKA STGDYKSDSE KGDSEDGEKK DHDKAKDEAP PQHSIEERRA PKKRLGLRKE
     PPEAFMASFL AGLEIYQTKM LNYLARNFYN LRFLALFVAF AINFILLFYK VTGDYSEDED
     PWNRRGREGE EEDEGALEYF VLQESTGYMA PTLRCLAILH TIISFLCVVG YYYLKKVPLV
     VFKREKEIAR KLEFAGLYIT EQPSDDDIKG QWDRLVINTL SFPNNYWDKF VKRKVIKKYG
     DLYGAERIAE LLGLDKSALD FNPTEETVAK EASLVSWLSS IDTKYHVWKM GVVFTDNSFL
     YLVWYTTMSI LGHYNNFFFA AHLLDIAMGF KTLRTILSSV THNGKQLVLT VGLLAVVVYL
     YTVVAFNFFR KFYNKSADDD EPDMKCDDMM TCYLFHMYVG VRAGGGIGDE IEDPAGDPYE
     LYRILFDITF FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI CGIGNDYFDT
     TPHGFETHTL QEHNLANYLF FLMYLINKDE TEHTGQESYV WKMYQERCWD FFPAGDCFRK
     QYEDQLG
//
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