ID A0A087Y4L0_POEFO Unreviewed; 587 AA.
AC A0A087Y4L0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=mRNA m(6)A methyltransferase {ECO:0000256|ARBA:ARBA00012160};
DE EC=2.1.1.348 {ECO:0000256|ARBA:ARBA00012160};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000012963.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000012963.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
CC Evidence={ECO:0000256|ARBA:ARBA00036277};
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
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DR EMBL; AYCK01004421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007551439.1; XM_007551377.2.
DR AlphaFoldDB; A0A087Y4L0; -.
DR SMR; A0A087Y4L0; -.
DR STRING; 48698.ENSPFOP00000012963; -.
DR Ensembl; ENSPFOT00000012981.1; ENSPFOP00000012963.1; ENSPFOG00000012920.1.
DR GeneID; 103137573; -.
DR KEGG; pfor:103137573; -.
DR CTD; 56339; -.
DR eggNOG; KOG2098; Eukaryota.
DR GeneTree; ENSGT00550000075058; -.
DR OMA; YPDGNSM; -.
DR OrthoDB; 179166at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0016422; F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0001734; F:mRNA (N6-adenosine)-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0098508; P:endothelial to hematopoietic transition; IEA:Ensembl.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0060853; P:Notch signaling pathway involved in arterial endothelial cell fate commitment; IEA:Ensembl.
DR GO; GO:0001556; P:oocyte maturation; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:1902036; P:regulation of hematopoietic stem cell differentiation; IEA:Ensembl.
DR GO; GO:0090365; P:regulation of mRNA modification; IEA:Ensembl.
DR GO; GO:0007530; P:sex determination; IEA:Ensembl.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025848; MT-A70.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12829:SF2; N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
DR PROSITE; PS51563; SAM_MTA70L_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 64588 MW; 41F753CB326637A8 CRC64;
MSDTWSNIQA HKKQLDSLRE RLKRRRKDPA QLSGTDGGLS AEGSTARSDS PAPSAPSTSQ
GETEQPPDPE LEKRLLGYLS DLSLSLPTDS LAITNQLNSA EGTVTHGCIQ SLLLKFSAQE
LIEVRQPTSI SSSSTTSSPP TTVVVAVDHT KLWAMIGSVS GAQRAGVKRK AEDQTLGGFS
PKLQSSASPP HASSSSITPA SSLQLAGSSA AGSGAEKKGR SSKSQSSHVD MEIESLLNQQ
STKEQQSKKM SQEILELLNA STAKEQSIVE KFRSRGRAQV QEFCDHGTKE ECVRSGDTPQ
PCTKLHFRRI INKHTDESLG DCSFLNTCFH MDTCKYVHYE IDSPPEAESS LMGPQSGTPE
IGLHAEDADS NVGKLFPSQW ICCDIRYLDM SILGKFSVVM ADPPWDIHME LPYGTLTDDE
MRKLSIPALQ DDGFLFLWVT GRAMELGREC LSQWGYERVD EIIWVKTNQL QRIIRTGRTG
HWLNHGKEHC LVGVKGSTQG FNRGLDCDVI VAEVRSTSHK PDEIYGMIER LSPGTRKIEL
FGRPHNVQPN WITLGNQLDG IHLLDPEVVA RFKERYPDGV ISKPHTQ
//
