ID   A0A087Y4Z4_POEFO        Unreviewed;       896 AA.
AC   A0A087Y4Z4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000013097.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000013097.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   EMBL; AYCK01014246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01014247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A087Y4Z4; -.
DR   STRING; 48698.ENSPFOP00000013097; -.
DR   Ensembl; ENSPFOT00000013115.2; ENSPFOP00000013097.2; ENSPFOG00000012602.2.
DR   eggNOG; KOG2514; Eukaryota.
DR   GeneTree; ENSGT00940000155840; -.
DR   OMA; KETCLHA; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF20; ANOCTAMIN-2; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        294..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        371..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        469..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        515..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        564..582
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        685..708
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        843..864
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          12..280
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          283..878
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   896 AA;  102927 MW;  B150BE6AC92C3E34 CRC64;
     PSSPQASSEG LYFCDGLRKV DYVLVFHHRR HGSLRCTGTA SVSQDQLSIV SNGNFPEEAA
     SVGEVFMELG MARGSEPMEA ADHEMHLIRQ EFEANLLEAG LEVERDRETK THGPSFTRIH
     APWPVLCREA EFLKIKVPTK QSYELREESG FGSSMSSVWR KLNQPFEPKV PHQDHGSTKF
     LSHCFSRDKL HMYNITSKDT FFDNATRGRI VYEILRRTVC VRTCQTIGIS TLIAKGVYDA
     AFPLHDGDFK VTGHLEERND RQVLFEEWAR YSAFYKYQPI DLVRKYFGEK IGLYFAWLGV
     YTQLLIPASI VGIIVFGYGV ATVDTNIPSL EMCDERLNFT MCPLCDGACD YWHLSTACGT
     ARASHLFDNP ATVFFAIFMS LWAVLFLEHW KRRQISLSFS WDLTGIEEDE AKPSRNSDEH
     PRPKYETILL EKRQRKQGYS TCHFVSSMSP YSFQTVAEKL TWKDRLPGYF MNISSILFMF
     GLTFSAVFGV IIYRITISAL MAMSPDPETK SNVRVTVTAT AVIINLVVIL ILDEIYGTVA
     LWLTELAEIP KTETNFEERL ILKAFLLKFM NAYAPIFYVA FFKGRFAGRP GSYVYVFNDY
     RMEECAPGGC LIELCVQLSI IMLGKQLIQN NIFEIGIPKL KKLIRTLKEK EPTQKEKDEE
     RPPRQWNLDY ALVPFEGLTP EYMEMIIQFG FVSLFVASFP LAPLFALLNN VIEIRLDARK
     FVTELRRPVA ARAKDIGIWY NILSGMGKLS VIINAFVIAF TSDFIPRLVY QYMYSQTGTM
     HGFIDHTLSF FNVSNFKPGT APHSDKFPQL FVFLRYKDYR EPPWSSDAYQ FSKQYWSVLS
     ARLAFVILFQ NLVMFLSLMV AWVIPDVPKT IVEQLKREKK LLVDLFLQEE KEKFQL
//