ID A0A087Y529_POEFO Unreviewed; 583 AA.
AC A0A087Y529;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Transcription factor 7-like 1-A {ECO:0000313|Ensembl:ENSPFOP00000013132.2};
GN Name=TCF7L1 {ECO:0000313|Ensembl:ENSPFOP00000013132.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000013132.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000013132.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
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DR EMBL; AYCK01000958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01000959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01000960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007564106.1; XM_007564044.2.
DR AlphaFoldDB; A0A087Y529; -.
DR STRING; 48698.ENSPFOP00000013132; -.
DR Ensembl; ENSPFOT00000013150.2; ENSPFOP00000013132.2; ENSPFOG00000012996.2.
DR GeneID; 103146213; -.
DR CTD; 30556; -.
DR eggNOG; KOG3248; Eukaryota.
DR GeneTree; ENSGT00940000157038; -.
DR OMA; HPLSWLV; -.
DR OrthoDB; 5351131at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR PANTHER; PTHR10373:SF25; TRANSCRIPTION FACTOR 7-LIKE 1; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 329..397
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 329..397
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 63787 MW; 820C24289C896F2F CRC64;
MPQLNGGGGD DLGANDEMIS FKDEGEQEEK ISENVSAERD LDDVKSSLVN ESENNSSSSD
SEQAERRPQT RPDSESYEKT RDYFGEALRR QQDGGFFKSP HYPGYQFLMF PDLTNPYLSN
GSLSPSARTY LQMKWPLLDV PGSAGIKDSR SPTPGHLSNK VPVVQHAHHV HPLTPLITYS
NEHFSPGTPP SHLSPEILDP KTGIPRTPHP SELSPYYPLS PGAVGSIAHP LSWFMQQQGQ
PMYSIPPGGF RHPYPTLAMN ASMSSLVSSR FSPHMVTPPP HSLHQTGIPH PAIVSPAIKQ
EPSGDNISPS MHAKSPVPSK KEEDKKPHIK KPLNAFMLYM KEMRAKVVAE CTLKESAAIN
QILGRRWHSL SREEQAKYYE LARKERQLHS QLYPGWSARD NYGKRKKRKR ENKPDSKPED
FSIRSKKQCV QYLPSEKMCD SPASSHGSML DSPATPSAAL ASPAAPAPTH SEQAQPLSLT
TKPEGRMHHH FSVPGKASGS ASSSSSSSSS SSSSSSSSQP SIAIPVGTLG SQSSTPILTR
PIPFTSLHPS MLSPPSPFHQ AALHSHHSLF QSQPLSLVTK PTE
//
