ID A0A087Y6L4_POEFO Unreviewed; 365 AA.
AC A0A087Y6L4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase {ECO:0000313|Ensembl:ENSPFOP00000013667.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000013667.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000013667.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; AYCK01009210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01009211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087Y6L4; -.
DR STRING; 48698.ENSPFOP00000013667; -.
DR Ensembl; ENSPFOT00000013686.1; ENSPFOP00000013667.1; ENSPFOG00000013637.1.
DR eggNOG; KOG1430; Eukaryota.
DR GeneTree; ENSGT00940000160236; -.
DR OMA; GDHFKRG; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF835; 3 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 7; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 12..279
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 365 AA; 41777 MW; 9D79790A52D4A7D3 CRC64;
TMEENKRTLV YLITGGCGFL GKHLLDVLLE KEEKLAEVRV FDKHIYPGFH EQRKTDEVEV
TLIQGDITDY NSVLEATKGV DVVIHSASLV DVWHKIPASL IYSVNVTGTE NVIRACVECG
VERLVYTSSM EVIGPNVKGD HFKSRGNEDT KYEVKHTMAY PKSKAKAENI VLRANGSQKY
VEVVLLLHGC NFLGSACYLK SFVLPSLQEK IWKFQSLKNQ TTLELTVQSN VAWMHVLAAR
ALKMNPEKVA GEAFFCYDES PYKSYEDFNM ELLSEFNFRK VCMPGIVLCF LAILNDFLRW
ILSPFYNYTP LLNRYTLAVA STTFTVQTDK AQRYFQYQPL YDWSQCLART QSWIRTFPAD
KQKDS
//
