ID A0A087Y741_POEFO Unreviewed; 1531 AA.
AC A0A087Y741;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Slit guidance ligand 1 {ECO:0000313|Ensembl:ENSPFOP00000013844.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000013844.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000013844.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AYCK01014816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01014817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01014818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01014819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007572666.1; XM_007572604.2.
DR STRING; 48698.ENSPFOP00000013844; -.
DR Ensembl; ENSPFOT00000013863.2; ENSPFOP00000013844.2; ENSPFOG00000013298.2.
DR GeneID; 103152224; -.
DR KEGG; pfor:103152224; -.
DR CTD; 556123; -.
DR eggNOG; KOG4237; Eukaryota.
DR GeneTree; ENSGT00940000157322; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45836:SF23; LRRCT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01463; LRRCT; 4.
DR Pfam; PF01462; LRRNT; 2.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 20.
DR SMART; SM00082; LRRCT; 4.
DR SMART; SM00013; LRRNT; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF52058; L domain-like; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 6.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1531
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001834079"
FT DOMAIN 927..962
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 964..1003
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1005..1041
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1043..1081
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1083..1119
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1124..1160
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1163..1336
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1337..1371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1374..1410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1415..1451
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1456..1531
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 952..961
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 993..1002
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1031..1040
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1071..1080
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1109..1118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1150..1159
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1339..1349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1361..1370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1378..1388
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1400..1409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1419..1429
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1441..1450
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1531 AA; 169050 MW; 97D391F34A8EB46A CRC64;
MPVGGFESSM GRLPRQWMWL LMLSALMVGN ASACPALCTC SGTTVDCHGL GLKTMPRSIP
RNTERLELNG NNLTRITKSD FAGLKYLRVL QLMENQITVI ERGAFDDMKE LERLRLNRNQ
LQQLPELLFQ KNPGLSRLDL SENFIQSIPR KAFRGATDIK NLQLDKNHIS CVEDGAFRAL
RGLEVLTLNN NNISSIPVSS FNHMPKLRTF RLHSNNLNCD CHLAWLSQWL RQRPTIGLFT
QCASPPELRG LNVAEVQKHE FTCSGHQESS SLQPCITGGG SCPAMCTCSN NIVDCRGKGL
TAIPANLPDS MSEIRLEQNG IKSVPPGTFS PYKKLRRIDL SNNQISEIAP DAFQGLRSLN
SLVLYGNKIT DLPKGVFDGL YSLQLLLLNA NKIHCVRANA FQDLQNLSLL SLYDNKIQTL
AKGTFTSLRA IQTLHLAQNP FICDCNLKWL ADYLRSNPIE TSGARCASPR RLANKRIGQI
KSKKFRCSAK EQYVIPGTED THLNNVCNTD PVCPPKCRCE SNVVDCSNLK LTKIPEHIPA
STAELRLNNN ELTTLEATGV FKNLSQLKKI NLSNNKITEI EDGAFEGASS VFELHLTANQ
IDSVRSGMFR GLEGLRMLML RNNKISCVHN DSFTGLHNVR LLSLYDNHLT TITPGAFDTL
QTLSTLNLLA NSFNCDCRLA WLGDWLRSRK IVTGNPRCQR PAFLKEIPLQ DVALPDFRCE
EGQEESSCVP RPQCPSECTC LETVVRCSNK HLHTLPKGIP RNVTELYLDG NQFSVVPKEL
SSFKYLQLVD LSNNKIYSLS NSSFANMSQL TTLILSYNSL RCIPKMAFSG LHSLRLLSLH
GNEISELPDG IFNDVTSLSH LAIGANPLHC DCHLRWLSDW VKTGYKEPGI ARCAGPQGME
SKLLLTTPAK KFECTGDVDN SVLAKCNPCL SNPCLNHGIC HNDPTEMYRC NCPPGFKGRN
CETALNGCVS SPCANGGTCQ VTDEDEGEYR CSCLPGFEGP TCQINVDDCE DNDCENGATC
IDGINNYTCF CPPYYTGEMC EEMEDVCAPG RSPCQHQSTC LISTSGPKCV CSPGYVGDDC
SVNYDDCREH RCQNGAQCVD ELNGYSCICP NGYSGQLCEV PPSPLSLCEL ADCQNNAPCV
ERGGRALCQC PPEFGGPRCE KLVSVNFVDR DSYLLLSDLK NWPQANITLQ VSTAEDNGIL
LYNGDNDHIA VELFQGHVKV SYDPGSQPGH AIYSTETIND GQFHTVELVT FDQMVNLSID
GGLPTTMDSF GAVRPLNGEA PLYVGGMPVD VHSGTFRLWQ IQNGSSFHGC IQNLYINNEL
QDFTKTQMKP GVVPGCEPCK KLYCVHGICQ PDGLQGPVCH CQPGWSGTHC DQPALNPCQG
SKCVHGKCIP LDLQSYRCEC EEGYRGALCN QQGELFNPCR RLTCKHGRCQ ISDSGDAYCH
CESGYTGELC DAESECRGEP VRDFYQVQRG YAICQTTRMV SWVECTGACD TGSCCVSQRM
KRRKYTFECS DGTSFTEEVE KTIKCGCVGC M
//
