ID A0A087Y7I5_POEFO Unreviewed; 861 AA.
AC A0A087Y7I5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL5 {ECO:0000313|Ensembl:ENSPFOP00000013988.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000013988.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000013988.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01008838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01008839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01008840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007561470.1; XM_007561408.2.
DR RefSeq; XP_007561472.1; XM_007561410.2.
DR AlphaFoldDB; A0A087Y7I5; -.
DR STRING; 48698.ENSPFOP00000013988; -.
DR Ensembl; ENSPFOT00000014007.2; ENSPFOP00000013988.2; ENSPFOG00000013862.2.
DR GeneID; 103144425; -.
DR KEGG; pfor:103144425; -.
DR CTD; 114879; -.
DR eggNOG; KOG2210; Eukaryota.
DR GeneTree; ENSGT00940000159535; -.
DR OMA; WESAKLW; -.
DR OrthoDB; 1018068at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13286; PH_OPR5_ORP8; 1.
DR Gene3D; 1.10.287.2720; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 6.10.140.1150; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF221; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 5; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT TRANSMEM 838..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 123..240
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 97701 MW; 1DD24074ECC87E98 CRC64;
MKEENLLQRR LSLCPSATSP PKIDPRTLTR NLSYGGDNDI YNFSPGSETD RNALSMLSSE
LSPAQSPDSK SESRMFNGVE KDSPSPTEKL ARKESLKVQK QNYRQEKKRA AKELSTALKD
PSVVVMSNWL KIRGSLKSWT KLWCALRPGV LLIYKTPTPD HWVGTILLSA CKLIERPSKK
DGFCFKLYHP LEKSIWAVKG PKGENVGSIT QPLPSNYLIF RAASESDGRC WMDALELALS
SSSLYKMSPR PEKEGDICMA SDSSHILQLL QSSPLTATEL QQLNHMEHDG SSDKSEREAH
DDWETMGNEN GGRLTEESDI EPSEEMPPGP QATAYVEQST EDMAEVGEAS QVETVSEENK
GLIWGLLKQL RPGMDLSKVV LPTFILEPRS FLDKLSDYYY HADLLSQASL EESAYGRIKQ
VLRWYLSGFY KKPKGLKKPY NPILGETFRC CWLHPQTDSC TFYIAEQVSH HPPISAFYVC
NRKDGFCISG SILARSKFYG NSLSAILDGQ ARLRFLSRDE EYAITMPYAH CKGFLYGTMT
LELGGKVIIQ CEKTKCFAEL EFKLKPFLGG TSSVNQISGK IVIEDELLAT IDGHWDKEVF
IQEKRSSQQE TLWNPTKEIR SRRLKRQVVQ LDQQGEFESE RLWQHVTRAI RDRDQVRATQ
EKFVLEEAQR TEAKERGQRP WIPKLFQEDP DTSEWTYKHL DTRPWDPEAC LVQFEKDGVI
QTQEKMQRQH NGLTYNNSWT RQHKAEVNGN HRKSSSQPST CSQNTESSST TPEPSHESSD
NEGFSNQCAR CSKEAKDIAL IQTSITSIQK TQQDIQRNLA ALGGQLSRQR HTDDSMSLTG
RHCLILCVLL LSQLLLNYVF T
//
