ID A0A087YAH1_POEFO Unreviewed; 921 AA.
AC A0A087YAH1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL6 {ECO:0000313|Ensembl:ENSPFOP00000015024.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000015024.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000015024.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR EMBL; AYCK01002208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01002209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087YAH1; -.
DR STRING; 48698.ENSPFOP00000015024; -.
DR Ensembl; ENSPFOT00000015046.2; ENSPFOP00000015024.2; ENSPFOG00000014393.2.
DR eggNOG; KOG1737; Eukaryota.
DR GeneTree; ENSGT00940000156791; -.
DR OMA; TNCVEMS; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 70..165
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..273
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 921 AA; 105203 MW; EFF34909EBD58667 CRC64;
MSLHHQYQRG PHGRTMSTEE RSSTPVNKTS VPVQKSASSS SSSQRDSRQE ADSWEIIEGL
KIGQSNVQRP DKHEGFMLKK RKWPLKGWHK RFFVLDNGIL KYSKTPIDIQ RGKLHGSIDV
GLSVMSIKKR ARRIDLDTEE HIYHLKVKSQ DIFDAWVSKL RHHRLYRQNE IVRSPREPTM
RTFPPPAAME TPQPSPIVVN ETKQAKSSSL PWQPAAPSSS SNSSLQASYS NGQSRVAAWL
QESEEMDKCA EELARCQSNL TELSRLLQSL EILQRTQSAP NFTDMQANCV ELSKKEKRLN
RRWRTKSVGK DAKFQLQVPL SASMSPVRLH SSNPNLCAEL GDYQPPVSRL SDSVEYASDY
FKLQEEFCTI AQKVHSLLKS AFNTVAIEKE KIKQVLSEQE QSDQSSQIIS IRKSLSLALA
QNAELRSRLN RIHSESILTE QVVSVNIIAT PDEAVEQMGI PLTQQASNES RLSMSESVSE
FFDAQEVLLS ASSSENEGSD DESYVSDVSD NISEDNASVT DNVSRQMANG DFAGSAFRNG
RRICLPAPCP DTSNINLWNI LRNNIGKDLS KVSMPVELNE PLNTLQRMCE ELEYSELLDK
AAETEDPFER MVLVAAFAVS GYSSTYYRAG SKPFNPLLGE TYECIREDKG FCFFSEQVSH
HPPVSACHCE SKNFTFWQDV RWKNKFWGKS MEILPIGSVN LTIPRFGDHY EWNKVTTCVH
NILSGRRWIE HYGEITIRNT KSSACLCKLT FVKGNYWSSN VNEVQGFVMD QEGKVIHRLF
GKWHEGLYCG IPPSAKCVWR PGSMPTDYEL YYGFTRFAIE LNELCPELKD ALPRTDARFR
PDQRYLEEGN VEMAGSEKQR IEDAQRARRK WNEENNIKHE PRFFKKVVDA NHRERWVSNN
MYWELRKNPG FINMEPTVSL W
//
