ID A0A087YAY7_POEFO Unreviewed; 919 AA.
AC A0A087YAY7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Circadian locomoter output cycles protein kaput {ECO:0000256|ARBA:ARBA00040572};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000015190.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000015190.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
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DR EMBL; AYCK01004518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007551745.1; XM_007551683.2.
DR RefSeq; XP_007551746.1; XM_007551684.2.
DR RefSeq; XP_007551747.1; XM_007551685.2.
DR AlphaFoldDB; A0A087YAY7; -.
DR STRING; 48698.ENSPFOP00000015190; -.
DR Ensembl; ENSPFOT00000015212.2; ENSPFOP00000015190.2; ENSPFOG00000015083.2.
DR GeneID; 103137774; -.
DR KEGG; pfor:103137774; -.
DR CTD; 352927; -.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00940000157580; -.
DR OMA; FIVCTHY; -.
DR OrthoDB; 2899615at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR GO; GO:0009648; P:photoperiodism; IEA:Ensembl.
DR CDD; cd19734; bHLH-PAS_CLOCK; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF2; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 24..74
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 97..145
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 275..322
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 104602 MW; 33F33F72717365D7 CRC64;
MTSSIGDDCS LTDGLMEEDE KDKAKRVSRN KSEKKRRDQF NVLIKELGTM LPGNTRKMDK
STILQKSIDF LCKHKEIAAQ SESSEIRQDW KPPFLSNEEF TQLMLEALDG FFIAIMTDGN
ILYVSESVTS LLEHLPADFV DQNLLNFLPV GEHSEVYKVL STHPTELESL SSDYMKTKNH
LEFCCHMLRG AIDPKEPPVY EYVKFIGNFK SLNNVPNITR NGLAGVLQRS LQPAFDDQVC
FVATVRLAKP QFIKEMCTVE EPNEEFTSRH SLEWKFLFLD HRAPPIIGYL PFEVLGTSGY
DYYHVDDLET LAKCHEHLMQ YGKGKSCYYR FLTKGQQWIW LQTHYYITYH QWNSRPEFIV
CTHTVVSYAE VRAEQRRELG IEETNPEAAV DKSQDSGSES QLNTSSLKEA LERFDHSRTP
STSSRSSRKS SSHVSDNTCT STAPKLHMDM ATPPRQSLAS TMEMTSQRRS SISSQSMSSQ
TTGQSLNPGM ITQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQLQANVQPV MEFSAQVNAM
QHLKEQLEQR TRMIQANIQR QQEELRHIQD QLQRVQGQGI QMLLQQQQQQ QSGTMNVQLQ
QVGSVQQAAT LTGQVQQPSV NPVHSGSQQL TIQQQAPPPQ QSLQQQTNTL AQRQPQQAAQ
AQPQAQGSVS APLYNTMMIS QPGPPNVLQI STSLPQNNTQ QGTAVATFTQ DRQIRFPAGQ
QLVTKLVTTP MHACGAVMVP TSMFMGQVVT AYNPFGGQQQ GGQTQTLTLQ PAQSSQGQPD
GQNQTAVVAQ NSQQGQQQQQ FLQGTRLLHS NQSTQLILQA AFPLQQQGAF TQATLPQQQQ
QQQQQQQQQQ HQQKQHQQQH QQQQQQQQQQ QQQQRQQKQQ QTQQHSHHQR HQQQLKPQPQ
KQQKASSSHR TDSVNHQQQ
//
