ID A0A087YAZ2_POEFO Unreviewed; 1164 AA.
AC A0A087YAZ2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Glutamate receptor, metabotropic 1b {ECO:0000313|Ensembl:ENSPFOP00000015195.2};
GN Name=GRM1 {ECO:0000313|Ensembl:ENSPFOP00000015195.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000015195.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000015195.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; AYCK01009002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087YAZ2; -.
DR STRING; 48698.ENSPFOP00000015195; -.
DR Ensembl; ENSPFOT00000015217.2; ENSPFOP00000015195.2; ENSPFOG00000015122.2.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234595; -.
DR OMA; INTGSWH; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR CDD; cd15449; 7tmC_mGluR1; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001256; GPCR_3_mGluR1.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF29; METABOTROPIC GLUTAMATE RECEPTOR 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF10606; GluR_Homer-bdg; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01051; MTABOTROPC1R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SMART; SM01229; GluR_Homer-bdg; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1164
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001834243"
FT TRANSMEM 587..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 585..847
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 871..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 130260 MW; 445C192FF51C0B89 CRC64;
LTVISNLYLP ILLFEAFVLS KVVPSSASRL VARMDGDVII GALFSVHHQP SAEKVAERKC
GEVREQYGIQ RVEAMFHTLD RINSDPNLLP NITLGCEIRD SCWHSSVALE QSIEFIRDSL
ISIRDDTEGS KWCIEGSPSS QPPPTKKPIA GVIGPGSSSV AIQVQNLLQL FNIPQIAYSA
TSIDLSDKTL FKYFLRVVPS DTLQARALLD IVKQYNWTYV SAVHTEGNYG ESGMEAFKEL
ASQEGLCIAH SDKIYSNAGE KHFDRLLRKL RERLPKARVV VCFCEGMTVR GLLMAMRRLG
VAGEFLLIGS DGWADRVEVV EGYEHEAVGG ITVKLHSEEV SSFDNYFLKL KLSTNTRNPW
FPEFWQHRFQ CRLPGHPQEN LNYARNCSGY ESLEDNYVQD SKMGFVINAI YAMAHGLHDM
HSHLCDGHVG LCDDMKPIDG SHLLEFLLKT SFTGVSGEDI WFDENGDSPG RYEIMNFQHV
EPGVYDYINI GSWHEGMLSL DDEMIHMNSS DMVRSVCSEP CSKGEIKVIR KGEVSCCWIC
TACKDNEYVQ DEFTCKACEL GWWPDEELEG CEPIPLHYLE WSNPESIIQV VFSCLGILVT
SFVAFVFVLY RDTPVVKSSS RELCYIILAG IFLGYLCPFT LIARPTVVSC YLQRILVGLS
AAMCYSALVT KTNRIARILA GSKKKICTRK PRFMSAWAQL VIASILISLQ LTLEVTLIIM
EPPEPIKSYP SIREVFLICN TSNLGVVAPL GYNGLLIMSC TYYAFKTRNV PANFNEAKYI
AFTMYTTCII WLAFVPIYFG SNYKIITTSF SVSLSVTVAL GCMFTPKMYI IIAKPERNVR
SAFTTSDAVR MHVGDGKIAC RSNSLLNMFK RKKNTGNGSS NGKSVSWSEP GARHPPKGDH
MWHRLSVHVK RQEAGSNQMA VIKPLTNTYQ NTAGEFSDLS TKTLYNVAEE DENDPLTYSS
PTTPPMMAHG QMPACDMTKE AAGDMELYSL ERLQQNSVIP QHCVTDRLQE EIVLNKFSSD
THELVDNVCL PPAVSGMPVY HQAHLIQQEP ILPVHLDPFD EEPVSPLEEE EEMESEQFGL
LQGYMYNNTQ IHDDDEEEED MIEVKLAMED SVALMPPSPF RDRSGTPISP FPNSPVSESV
LCTPPNVTYA SVILGDYKQS ASTL
//
