ID   A0A087YC59_POEFO        Unreviewed;       421 AA.
AC   A0A087YC59;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Basic helix-loop-helix family member e41 {ECO:0000313|Ensembl:ENSPFOP00000015612.2};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000015612.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000015612.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AYCK01001897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007545587.1; XM_007545525.2.
DR   AlphaFoldDB; A0A087YC59; -.
DR   STRING; 48698.ENSPFOP00000015612; -.
DR   Ensembl; ENSPFOT00000015634.2; ENSPFOP00000015612.2; ENSPFOG00000015542.2.
DR   GeneID; 103133677; -.
DR   KEGG; pfor:103133677; -.
DR   CTD; 79365; -.
DR   eggNOG; KOG4304; Eukaryota.
DR   GeneTree; ENSGT00940000161014; -.
DR   OMA; KKPKMNW; -.
DR   OrthoDB; 2968390at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR   GO; GO:0030431; P:sleep; IEA:Ensembl.
DR   Gene3D; 6.10.250.980; -; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR   PANTHER; PTHR10985:SF76; CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 41; 1.
DR   Pfam; PF07527; Hairy_orange; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00511; ORANGE; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF158457; Orange domain-like; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT   DOMAIN          45..100
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          132..167
FT                   /note="Orange"
FT                   /evidence="ECO:0000259|PROSITE:PS51054"
FT   REGION          209..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..389
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..421
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  46337 MW;  B772A17038EF5CB1 CRC64;
     MDERIPHLQD RQFMEHADFL GMDFPPLYMC KSKRGIKRED SGKDAYKLPH RLIEKKRRDR
     INECIGQLKD LLPEHLKLST LGHLEKAVVL ELTLKHLNAL TAVTEQQHQK IIALQNGDRS
     LKPPIHTDLD AFHSGFQTCA KEVLQYLSQA ENWTAREQRC AQLINHLHKV LAQFQPDAPP
     LQHQLPAGDA QDAQKSDCQT NCVPVIQRTQ GGELNENDTD TDSGYGGEAE KSDGKDKECE
     RNKAVKIKQE FGDDRAAKKT KMCWSGNADP TRPDVAFMNS LMGLSGVGQQ TPICMPFYFI
     NPSAAAPYMP FFDKSNIEKY MYPAAAALAS PFPWLYPAHA SAAAAAAAAA AFPGLSAHLG
     AAAQPKDSQL QDDSGSREAE ASSPEEHEET PASDDGEGDV DDTSPDSKNS PQEQLSACQT
     S
//