ID A0A087YCJ7_POEFO Unreviewed; 991 AA.
AC A0A087YCJ7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Nucleotide-binding oligomerization domain-containing protein 2 {ECO:0000256|ARBA:ARBA00044203};
DE AltName: Full=Caspase recruitment domain-containing protein 15 {ECO:0000256|ARBA:ARBA00044293};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000015750.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000015750.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR EMBL; AYCK01004724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087YCJ7; -.
DR STRING; 48698.ENSPFOP00000015750; -.
DR Ensembl; ENSPFOT00000015772.1; ENSPFOP00000015750.2; ENSPFOG00000015686.1.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000160934; -.
DR OMA; HCCWPDA; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0060333; P:type II interferon-mediated signaling pathway; IEA:Ensembl.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF64; NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 2.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 8..99
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 111..191
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 277..413
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 991 AA; 110436 MW; F1E89791691E71A9 CRC64;
MKTCLPQELL LKRRAEILHA LCSSGSAEHL ERVMDMLLAQ GELGWEDCQN VLVPGRALYS
NARQLLDLVY TKGADSCELF FSAVKQVLPE ALGDALFLSG CHSTLDYTEK PQRTSTEELL
SQRPDLVLKL QGCIDGALRA LVESGHFSST DCDGIQLPIY TPSQQARRLL DLVRSKGESA
SLAVLQFVQQ SLESESSLEQ TNPNLTNEFV KYQKKLKSSV SAQSRFLSTY GGTSHMPLDD
IYTEVQMELP SNSSDNYKSM SFEEIIGPVG TVNDDADTVL ASGEAGSGKS TWLQRLHLLW
AQGKALQDFL LLFPFSCRRL NSEQRDLSVQ ELLFQHCCWP DRGQEEIFQF ILDHPHLVLF
TFDGLDELKQ SFADEQRICC PSQRAPVHVL LFNLIQGSLM KGVRKVVTSR PEAVGPALKK
HLHKEIHLKG FSPSGIDCFV RKHHSDPNEA AKVLESLQAN TALLGLCHSP VLCWIVSQCH
KELLGCGEGS LQTITDVYLM ILQHFFQHHS TVKSPIGVNW LQENLGTVLH LGQLAFEGIS
NSSYIFSVTD METCGVTESD ICMGFLIQSK DMSLANSKCY EFLHITLQCF LAALFAILSR
NSGCSAISKL FELQEMKKKR LRGTCFGACL NSTNTPNIAE EHSTMAETPN LQITATFVSG
LLSQRYQKLL FQCSSSVLVE RKTKHAEKCL SKGMQQHFRS IPQPVQGEKK SMHAMPEFVW
LIKCIYEMQN SRLAKDAMSK LEAEHLKLTY CNIGPVECTA LAYVLQHLKN PVGIQLDNNS
VGDVGVEQLL PCMHICSSLY LRNNNITDEG IRKLIDKVIH LQNFQKIALF NNRLTDACTK
HFSYLLKTRQ NFLSLRLGNN NITAKGAKQL AEGLKFNHSL QYLGLWGNKI GDEGAEALAN
ALQNSESIVW LSLVGNGVGS AGACAISNII KNSTSLEDLW LTENCITRTG VESLTQALKH
NHHVKSVWLK NNDLTSAEIE EMEQIESRLV F
//
