UniProt: A0A087YD83

Database: UniProt
Entry: A0A087YD83_POEFO

LinkDB:  A0A087YD83_POEFO 
Original site:  A0A087YD83_POEFO

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Ontology (6)   
   GO (6)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (12)   
   InterPro (9)   
   Pfam (2)   
   PROSITE (1)   
All databases (26)   

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ID   A0A087YD83_POEFO        Unreviewed;       491 AA.
AC   A0A087YD83;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   24-JAN-2024, entry version 50.
DE   SubName: Full=Gamma-aminobutyric acid receptor subunit gamma-3-like {ECO:0000313|Ensembl:ENSPFOP00000015986.2};
GN   Name=GABRG3 {ECO:0000313|Ensembl:ENSPFOP00000015986.2};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000015986.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000015986.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic
CC       cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC       {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034099}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       {ECO:0000256|RuleBase:RU000687}.
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DR   EMBL; AYCK01006790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01006791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007557137.2; XM_007557075.2.
DR   AlphaFoldDB; A0A087YD83; -.
DR   STRING; 48698.ENSPFOP00000015986; -.
DR   Ensembl; ENSPFOT00000016008.2; ENSPFOP00000015986.2; ENSPFOG00000015891.2.
DR   GeneID; 103141432; -.
DR   KEGG; pfor:103141432; -.
DR   eggNOG; KOG3642; Eukaryota.
DR   GeneTree; ENSGT00940000155607; -.
DR   OMA; HHDTTVN; -.
DR   OrthoDB; 4265336at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro.
DR   CDD; cd19054; LGIC_TM_GABAAR_gamma; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR005437; GABRG-1/4.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   NCBIfam; TIGR00860; LIC; 1.
DR   PANTHER; PTHR18945:SF195; GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-3; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR01620; GABAARGAMMA.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Chloride {ECO:0000256|ARBA:ARBA00023214};
KW   Chloride channel {ECO:0000256|ARBA:ARBA00023173};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR605437-50};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW   Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT   TRANSMEM        297..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        363..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        471..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   DOMAIN          92..297
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
FT   DOMAIN          304..412
FT                   /note="Neurotransmitter-gated ion-channel transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF02932"
FT   DISULFID        215..229
FT                   /evidence="ECO:0000256|PIRSR:PIRSR605437-50"
SQ   SEQUENCE   491 AA;  56805 MW;  FD550D6EBED0964C CRC64;
     MGTHLLHAAA AAETAAAAAR AGVPVQQFPQ AELPSARGKM TVRLAVTLFT LLLLTQDARS
     DLLEYGDDEE DLHDTTVNQM LVPRSHQEDA TLILNNLLRE YDKTLRPDIG EKPTVIDVGI
     YVNSIGPVSS IDMEYQIDII FAQTWVDTRL RYNSSSMRIL TLNSNMVGLI WLPDTIFRNS
     KNADSHWITT PNQLLRIWNN GKILYTLRMT INAECQLQLH NFPMDEHSCP LEFSSYGYPR
     DEIMYKWKRN SVETSDQKYW RLYQFDFMGL RNTTDVLRTT AGDYVLMTVY FDLSRRMGYF
     TIQTYIPCIL TVVLSWVSFW IKSDATPART TLGITTVLTM TTLSTVARNS LPRVSYVTAM
     DLFVTVCFLF VFAAMIEYAM LNYYSYSIRR PPPKMQRMAY SSFNMGRTPR AMMPMGNSLF
     WHDYDDNCLY ECLDGKDCKS FFCCFEECKE GGWRKGRIHL NIRELDSYSR VFFPTSFLLF
     NIVYWVSYLY L
//

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