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Database: UniProt
Entry: A0A087YDC8_POEFO
LinkDB: A0A087YDC8_POEFO
Original site: A0A087YDC8_POEFO 
ID   A0A087YDC8_POEFO        Unreviewed;      2684 AA.
AC   A0A087YDC8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   16-JAN-2019, entry version 21.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 2 {ECO:0000313|Ensembl:ENSPFOP00000016031};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000016031, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000016031, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000016031};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000016031}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AYCK01001897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01001898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000016053; ENSPFOP00000016031; ENSPFOG00000015617.
DR   GeneTree; ENSGT00940000156039; -.
DR   OMA; ENQVKGG; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2221   2245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2257   2273       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2302   2322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2342   2367       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2387   2409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2506   2529       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    356       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      390    446       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2616   2664       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2684 AA;  307977 MW;  4C9E294AB8DF5754 CRC64;
     MSEHKSSFLH IGDIVSLYAE GSVNGFISTL GLVDDRCVVQ PDAGDLANPP KKFRDCLFKV
     CPMNRYSAQK QFWKAKQGKQ GNNNTQAELF KKLQHAAELE QKQNETENKK LLGDIVKYSS
     VIQLLHIKSN KYLTVNKRLP ALLEKNAMRV SLDPAGNEGS WFYIQPFWKL RSEGDNVVVG
     DKVVLMPVNA GQPLHASNIE LLDNRGCKEV NALNCNTSWK VTLFMKFSDY REDVLKGGDV
     VRLFHAEQEK FLTGDEYKKQ QHVFLRTTLR QSATSATSSK ALWEIEVVHY DPCRGGAGQW
     NSLFRFKHLA TGNYLAAEMN PEFKNGTAES QREILRWTKF LMSKNETDAG FSKRKNQASE
     RIAFTLVSVP HGNDIASLFE LDATTLQRAD CLVPRNSYVR LRHLCTNTWV TSTNIAIDTE
     EERPVMLKIG TCSTKEDKEA FAIVSVPLSE VRDLDFANDA NQVLESTVRK LKFANITQNE
     RRFVTTLLED LIFFVCVVPN NGQDVLSVVT STPNRERQKL MREQNILSQQ IFGILTAPFK
     DNGDGPMLRL EELGDQRYSP FKYMFRLCYR VLRHSQQDYR KNQEYIATKF PIMQSQMGYE
     ILAEDTITAL LHNNRKLLEK HITAREIETF VSLLRRNREP RFLDYLSDLC ASNKTAIPVT
     QELIIKFMIN PANADILIQT KLISNSENSM DSSLSPDDGD EEEVWLYWID IHKEPHGKSI
     RHLAQDAKNN HKIDADLLTY YRCQLNLFAK MCLDRQYLAI NQINDKLPVD LILRCMFDDC
     LPYNLRASFC RLMLHMHVDC EPQEAVVPVR YARLWTEIPS KISIKEFKYE STVDSREEMK
     KKFKSTMEFV DDYLKDVFNQ RYPFGDKEKN ELTLEVVNLA RHLVYFGFYN FSELLRLTRI
     LLAILDIVQQ PFSLLSKLGK TPEAGNNVLR TIHGVGELMT QMVMSRGVPH SLPDMPPSLR
     YTVGQFLPDN EDVVVMDTKL KIIEILQFIL SVRLDYRITY LLSIYKKEFG ESTMPESCSS
     MADYPPITSS EPNMDEIAAK AESMFVGSSS ALSVLELDDE GGRTFLRVLI HLIMQDYPPL
     VSGSLQLIFK HFSQRAEMLQ AFKQVQLLVS EQDVLNYTQI KEDLDRLRLT VEKSELWVEK
     SGIYGNDELG VRQSEEPTDY DDAVLSPVQD GENKPQMDSN QENNYEVLKC ILERFSRLCC
     VSKKNRLQLQ RLLKNMGAHT VVLELLQIPY EKNDEKMNEI MKLAHSFLQN FCKGNPENQV
     LLHKHLNLFL TPGLLEAETM RHIFMNNNQL CNEISDRVVH HFVHCIETHG RHVQYLKFLQ
     TIVKCDGKYM KKCQDKVMTE LVTAGEDVLV FYNDRSSFSV LLQMMASEQE RTDENGPLAY
     HNTLVDLLAA CTEGKNVYTE LKCNSLLPLD DIVKVVTDVN CVPEVKTSYV NFVNHCYVDT
     EVEMKEIYTS SHIWRLFENF LVDMATMCNT TERNRPDPLD KYVTETVMAI IRSFFESPFS
     VNYSMLQNNQ STFIKLLQSA FRIYNLKGIN SAQKSSIETC IKALADVAKA RSIPIPVDLD
     SQVNALSLNV HTNAVQRAAK DWRTSARSRP RKEPLGSPDY KNIIEKLQGV VSYLEDQFCP
     RVQAEFSVLV DVLQSPELLF PEAARSRCES GAFMSKLIKH TKQLMEQEEK LCIKILETIR
     EMMEKKESFQ ESGNELRKIL LTRYFGTQKL YSKSEGGSGN SSSGNVGSPA SLDSDKPCSS
     MVEIQCLLDK VGATELVIDL IVSTKNDRVF EQSILLGIAL LKGGNTQIQN SFYNQLFKQK
     NSEKFFKVFY DRLRMAQQEI RSTVSVNMFD FSSRKREDDN SFYSTRIWND SSIYMREEMR
     GQLKEASSAT SKAISSYRNE LDPDLELLGQ NSDAGGADEV EEEPEMSWSI AIMKPVLRYL
     QLLCENHNSD LQNFLRYQHN KTNYNLVCET LQFLDCICGS TTGGLGLLGL YINENNVDLV
     RQTLETITEY CQGPCHENQT CIAKHESNGI DIIIALIVNS INPLGENRLD LVLVLKNNAS
     KLLLAIMESR HDSENAEKIL YKMRPTELVD VMKEAYTQGY DAEGDIDNAG ERIKPRDVGH
     NIYILAHQLA RHNKILQQSL RPSLGLDNDK DEALRYYAKH TAQIEIVRHD RSMEQIVFPV
     PNICEYLTEE SKNRVFTTTE RDDQGSKVND FFQQFDNLYN EMRWQKKIRR NKALFWFSRH
     FSLWGSISFY LACVLNLTVG AFYPFGDDGD EGTLSPFWNI FLWVALGVST ALLPVLPKQW
     GIVSFLVSLI LRAIYTMGLT PALFLLGSIN LFNKLVFLVS FVGNKGTFAR GYKAVVMDLL
     FIYHLGYALI CVLGLFVHEF FYLFDLVFRE ETLLNVIKSV TRNGRSIILT AILALFLVYF
     FSIIGYIFFK NDFRMEVDHL HAKRPDMLCD VESADSSTKN SCPASPSKSR PERYEDDEVE
     RVCDTLRMCI ITVLNQGLRN GGGVGDILRR PSKEEPLFAA RVIYDLLFFF IVIIIVLNLI
     FGVIIDTFAD LRSEKQRKEE ILKTSCFICG LERDKFDNKT VSFEEHIKSE HNMWHYLYFL
     VLVRVKDPTE YTGPESYVAQ MIAEKNLDWF PRMRAMSLVS NEGDNEQNEI RSLQEKLENT
     VCLVSQLSSQ LYELKEQMTE QRKNKQRLGF LGPSQHNHHH IPTH
//
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