ID A0A087YFF5_POEFO Unreviewed; 1666 AA.
AC A0A087YFF5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=RPTOR independent companion of MTOR complex 2 {ECO:0000313|Ensembl:ENSPFOP00000016758.2};
GN Name=RICTOR {ECO:0000313|Ensembl:ENSPFOP00000016758.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000016758.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000016758.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RICTOR family.
CC {ECO:0000256|ARBA:ARBA00008878}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01000980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000016758; -.
DR Ensembl; ENSPFOT00000016780.2; ENSPFOP00000016758.2; ENSPFOG00000016545.2.
DR eggNOG; KOG3694; Eukaryota.
DR GeneTree; ENSGT00390000002096; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR028267; Pianissimo_N.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029259; RICTOR_phospho.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14664; RICTOR_N; 1.
DR Pfam; PF14665; RICTOR_phospho; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01308; RICTOR_N; 1.
DR SMART; SM01309; RICTOR_phospho; 2.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 4..386
FT /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01308"
FT DOMAIN 470..689
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 867..939
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 966..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1666 AA; 185481 MW; 550CCFEB72758B1B CRC64;
MRKLGHLNNF IKLLCNIGHQ EENFGFTYEE IIVCLRLALL NEAKEVRAAG LRALRYLIRD
TNVLQKVLRL QVDYLISRCI DIQQSNEGER TQALRLVRKI ITVNAMLFPT SVANSLIAVG
TDGLQERDRM VRAAVAIICE LALKNPEVVA KRGGLSTILK SVIDCQLSRI NEALITTVLH
LLNHPCTRQY VRVDVELEQI LAPFTDFHYR HNADTAEGQL KEDRESRFLS SRMAIVAAFR
SWSGIINLCK AGNSGIQSLI GLLCIPNMEV RKGLLEVLYE IFRLPVPIIT EDFTEALQSV
DPARFQDTWR LSDGFVAAEA KVILPHRARS RADLMDNYLA FVLSAFITSG LLEGLVEVVT
SSDDQLATRA TILLGELLHM ANTILPHSHS HHLHCLPTLI NMAASFDIPQ EKRLRASAAV
NNLKRFHEKK KKGLKPYSLY LDHIIRKSVS SHSRRDSHSR VQRDIYVIKD TEETLLMNLR
DSHILNHKQN LEWNWLLIAT ILKWPNVNLR NNKDEQMHRF VRRLLYFYKP TSKLYAGLAL
DHVKARQLTV VGCQFVEFLM DSDEDGQGYL EDLVRDMVSW LCSCSGLKPE RSLQSNGLLT
TLSQHYFLFL GTLSAHPQGV KMLEKCGLFQ CLLNLCSVKN QDAVLKLAVT TLDYSRDGLA
RVILSKVLTA STDTCRLYAT KHLRVLLRAG VEFFSSWGME LLVTQLHDHN KVVSMEALDI
LDEACEDKAN IHALIQLKPA VSHLGDKGLL LLLRFLSIPK GFSYLNERGY VSKQLDKWQK
EYNLKYVDLI EEQLNEALTT YRKPVDGDNY VRRSNQRLQR PNVYLPVHLY GQLVHDKTGC
HLLEAQNVVP DLSYTVRSPM LDTWEGVKQL KAALWALGNI GSSNWGLNLL QEENVIPDIL
ALAQHCEVLS VRGTCIYVLG VISKTKQGCE VLKQYGWDAV RHSRRTLWPV TPDEVDTQLT
SELSSVPSTL SLNSESTSSR HNSESESQPN MYILDDDKCD GLDSSDDPSF YPHSKAVKDR
SPFTILGSTR FVRPRFLNSL SLPSKKLRST SDPKSFSGSR TPTDLKTESP RRNRTVTEPS
VYSPNQGDVF TSVFNSRGMP KSPTVSLETS FVGTRGGSEE QLVDGRLVRG GGSGLGLSGL
AGHGVAEHHR EQSSRERLGG DGGSSGGGGG GTQFKSRSQS FNTDTTTSGI SSMSSSPSRE
TVGNPEHPEV EPDSSDCVSL NTVVSAKTVK TLSSLSPQPQ TNHLSASKSS NVSLVPLGSS
HTLPRRAQSL KSPSVTTIKS LADCSFIYTS PRDALGYATL KRLQQQRIHP SLSHSEALAS
PAKDVLFTDT ITMKTGSLDS RLTPRRFLKA LSFASLDKEE LLSPINQSTL QRCSSVRSMV
SSATFGCNDD YIGLALPMNI NDMFHIRDST YFQQRISPPS EERKRFLFGD GDGERPALPL
LKQQFSISEL IASRGETQNH LVDSEETGLQ DHSEENCLYC VGASVLGYPT QPQINSTHSR
TDYVDFPSWG GQGGHRLEVM PQSKFSGVSG CSDAAVSQGS ICSTPTPGDI VIGGKAISDD
GPASRVLLRK EILRLIINLS SSVGTKGHET GLLTIKEKFP YAFDDICLYS EVSHLLSHSM
FRLTSRRFIQ ELFQDVQFMP MYEEAEAILT KLPKPMEEDV NPPAES
//
