ID A0A087YFP4_POEFO Unreviewed; 585 AA.
AC A0A087YFP4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Geranylgeranyl transferase type-2 subunit alpha {ECO:0000256|ARBA:ARBA00014772, ECO:0000256|RuleBase:RU367120};
DE EC=2.5.1.60 {ECO:0000256|ARBA:ARBA00012656, ECO:0000256|RuleBase:RU367120};
DE AltName: Full=Geranylgeranyl transferase type II subunit alpha {ECO:0000256|RuleBase:RU367120};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000016847.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000016847.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from
CC geranyl-geranyl pyrophosphate to cysteines occuring in specific C-
CC terminal amino acid sequences. {ECO:0000256|RuleBase:RU367120}.
CC -!- FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from
CC geranylgeranyl diphosphate to both cysteines of Rab proteins with the
CC C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A
CC and RAB7A. {ECO:0000256|ARBA:ARBA00002902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] =
CC diphosphate + S-geranylgeranyl-L-cysteinyl-[protein];
CC Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533,
CC ChEBI:CHEBI:86021; EC=2.5.1.60;
CC Evidence={ECO:0000256|ARBA:ARBA00001577,
CC ECO:0000256|RuleBase:RU367120};
CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit alpha
CC family. {ECO:0000256|ARBA:ARBA00006734, ECO:0000256|RuleBase:RU367120}.
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DR EMBL; AYCK01004053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007550708.1; XM_007550646.2.
DR AlphaFoldDB; A0A087YFP4; -.
DR STRING; 48698.ENSPFOP00000016847; -.
DR Ensembl; ENSPFOT00000016869.2; ENSPFOP00000016847.2; ENSPFOG00000016750.2.
DR GeneID; 103137094; -.
DR CTD; 5875; -.
DR eggNOG; KOG0529; Eukaryota.
DR GeneTree; ENSGT00550000075121; -.
DR OMA; PKSYNAW; -.
DR OrthoDB; 5489560at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0004663; F:Rab geranylgeranyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0097354; P:prenylation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.120; Protein prenylyltransferase; 1.
DR Gene3D; 2.60.40.1130; Rab geranylgeranyltransferase alpha-subunit, insert domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002088; Prenyl_trans_a.
DR InterPro; IPR036254; RabGGT_asu_insert-dom_sf.
DR InterPro; IPR009087; RabGGT_asu_insert-domain.
DR PANTHER; PTHR11129:SF2; GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11129; PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT; 1.
DR Pfam; PF14580; LRR_9; 1.
DR Pfam; PF01239; PPTA; 5.
DR Pfam; PF07711; RabGGT_insert; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF48439; Protein prenylyltransferase; 1.
DR SUPFAM; SSF49594; Rab geranylgeranyltransferase alpha-subunit, insert domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS51147; PFTA; 5.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Prenyltransferase {ECO:0000256|ARBA:ARBA00022602,
KW ECO:0000256|RuleBase:RU367120};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU367120}.
FT DOMAIN 264..364
FT /note="Rab geranylgeranyltransferase alpha subunit insert-
FT domain"
FT /evidence="ECO:0000259|Pfam:PF07711"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..214
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 585 AA; 67734 MW; E891DB0D65B48DBD CRC64;
MHGRVKVKTT AQQEEEKRKE REKKLKVYVA ARDACFSKRK DGVFDDEALQ LTQQLLSANP
DFATLWNYRR EILTHLETVK DEDEAQKIYE AELSFLESCL KVNPKSYGSW HHRGWVSARL
PRPDWARELR LCDRCLSLDD RNFHCWDYRR MVVKMSSVPV KQELEFTDRL IGSNFSNYSS
WHYRSTLLPL LHPGSPEPPP SRCDGDPPHS CSPPSPQTHF HRVCEEQLLK EYELVQNAFF
TDPNDQSAWF YYRWLLGRAE REEMISCAYV SREQERVAVA FSRPVNAQSG SLLLVLDGQP
QRVEWRSVHP HFKHSPVWIC DLPPGTISDI ANEHNLTVHW TEKHTHRDCA LYTGRSESWC
RDTATDLELF RSELSVEKTS VLQSELQSVN QLQELEPLNK WCLLTIILLM RALDPLGYEK
ETLAHFQTLK EVDSMRSAYY SDLCSKFMIE NTILKMEYAE VRVFSISDRN LTTLCHLDQL
LLVTHINLSS NQLRRLPPQF AMLQCLEVVE ADNNSIENLE GVYHLPKLEE VSLKNNKIST
LADLQPLASC PKLRRLDLRG NPVTQTANVE SELAELLPSV ADLLL
//
