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Database: UniProt
Entry: A0A087YGF8_POEFO
LinkDB: A0A087YGF8_POEFO
Original site: A0A087YGF8_POEFO 
ID   A0A087YGF8_POEFO        Unreviewed;      1616 AA.
AC   A0A087YGF8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   28-MAR-2018, entry version 22.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000017111, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000017111, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000017111};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000017111}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AYCK01002216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01002217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000017133; ENSPFOP00000017111; ENSPFOG00000016943.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 3.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 2.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1616       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5001834496.
FT   TRANSMEM    124    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    351    375       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    387    408       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    470    495       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    557    580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    828    846       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    867    886       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    892    913       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    944    970       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1063   1087       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1137   1159       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1179   1198       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1210   1229       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1263   1291       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1369   1392       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    154       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      357    584       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      594    768       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      792    822       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      826   1096       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1145   1402       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      159    193       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1616 AA;  184129 MW;  49C6FFF01F8D8D44 CRC64;
     MILTVFCLSV FALVGLQLFM GNLRNKCIRI SEDTNLTFDE SYINNRSNQY ILQGKRDALL
     CGNSSSAGQC PEGFRCLKGG KNPDYDYTSF DNFGWAFLSL FRLMTQDYWE YLYQQTLRVA
     GKPYMIFFVL VIFLGSFYLI NLILAVVAMA YEEQCQVNLK KAQEKEYEYN IAIEQLKRQQ
     EDAQAMAKAA AATNGDALDK GGGTESSSEV SKLSSKSAKE RRNRRKKRKE EEKGARKISH
     SDSLDSLPAN RFHFSVDEHP LNYDMKCSST HQADTTDTEG KPTSGENYLN SLELPEMRQR
     ALSIASVITT TMEELEESRQ KCPPYWYKFA DKFLIWECCP LWLKIKEIVK IIVMDPFTDL
     AITLCIVLNT VFMAMEYYPM DPWFTDMLYV GNLVFTAIFT AEMVLKVIAL DPYHYFQVGW
     NIFDGVIVCL SLIELSLADV KGMSILRSFR LLRVFKLAKS WPTLNKLIKI IGNSVGALGN
     LTLVLAIIVF IFAVVGMQLF GKYYKDCVCK ISEDCTLPRW HMNDFFHSFL IVFRVLCGEW
     IETMWDCMEV AGKAPCLILY MTVMVIGNLV VLNLFLALLL SSFSADNLMS GEDDNELNNL
     QIAFDRIHRA IAFIKLKFRS CCNGLCIRDK KTTEDKTFGH NGVPNHTIKD LTKNSNGEVT
     GVDKSGNKYI VNSRSDDSIM SFINNPSLTV TVPIAAEESD FEMLNTEDFS SFSSNIPECH
     MVVDGDDDDG QFSTSEGSTV DGLSNGEPAE LVPVVEVIKE PHDCFTAGKL SNIHLTVLLL
     ITLQINNTLF FSGCIQKCKC CQVNANVGWW KVWWTLRKTC YRIVEHNWFE SFIIFMILLS
     SGALAFEDIY SEQRKTIKVI LEFADKMFTF IFILEMLLKW MAYGFAKYFT NAWCWLDFLI
     VDVSLVSLVA NALEYSELGP IKSLRTLRAL RPLRALSRFE GMRVVVNALM GAIPSIFNVL
     LVCLIFWLIF SIMGVNLFAG KFYRCENTTT EKPFLPTEVK NETECKSYGV WKNVKVNFDN
     VAMGYLALLQ VATFKGWMDI MYAAVDSQSK AGDQPEYEIN LKMYIYFVVF IIFGSFFTLN
     LFIGVIIDNF NQQKRKLGGQ DIFMTDEQKK YYNAMKKLGS KKPQKPIPRP ENKLQGYVFD
     FVTQQVFDIA IMVLIWLNMV TMMVEVEGQS KEWEKNLKYI NIVFIIIFSG ECLLKMIALR
     QYFFINGWNI FDFIVVILSI VGIFLANVIE KYFVSPTLFR VIRLARIGRV LRLIKSAKGI
     RTLLFALMMS LPALFNIGLL LFLVMFIYAI FGMSNFAYVK KEKGIDDLFN FETFGNSMIC
     LFQITTSGGW DLLLAPILNT KDNSDCDSEM EHPGSNNAKG NCGNPAVGIA FFVSYIIICF
     LIVVNMYIAV ILENFGVATE ESAEPLSEDD FEIFYEVWEK FDPLATQFVK YSMLSDFADS
     LAPPLRIPKP NKLELISMDL PVVSGDRIHC LDILFAFTKR VLGESGEMDI LRGQMEERFM
     AANPSKVSYE PITTTFRQKQ EDASAAVIQR AFRHYTRTKI FDVVRVDIEK DEQLTDKEDC
     CTEKPVELTT THKTEVSGLK DSEPSSTSVT PNVNSKHEKD RSEKEVESKD ITEQDK
//
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