ID A0A087YGF8_POEFO Unreviewed; 1616 AA.
AC A0A087YGF8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000017111.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000017111.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; AYCK01002216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01002217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000017111; -.
DR Ensembl; ENSPFOT00000017133.2; ENSPFOP00000017111.2; ENSPFOG00000016943.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000163423; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 2.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1616
FT /note="Sodium channel protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001834496"
FT TRANSMEM 124..151
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 351..375
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 387..408
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 470..495
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 557..580
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 828..846
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 867..886
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 892..913
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 944..970
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1063..1087
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1137..1159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1179..1198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1210..1229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1263..1291
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1369..1392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1..154
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 356..585
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 594..770
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 790..822
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 826..1096
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1145..1402
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 194..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 159..193
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1594..1616
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1616 AA; 184129 MW; 49C6FFF01F8D8D44 CRC64;
MILTVFCLSV FALVGLQLFM GNLRNKCIRI SEDTNLTFDE SYINNRSNQY ILQGKRDALL
CGNSSSAGQC PEGFRCLKGG KNPDYDYTSF DNFGWAFLSL FRLMTQDYWE YLYQQTLRVA
GKPYMIFFVL VIFLGSFYLI NLILAVVAMA YEEQCQVNLK KAQEKEYEYN IAIEQLKRQQ
EDAQAMAKAA AATNGDALDK GGGTESSSEV SKLSSKSAKE RRNRRKKRKE EEKGARKISH
SDSLDSLPAN RFHFSVDEHP LNYDMKCSST HQADTTDTEG KPTSGENYLN SLELPEMRQR
ALSIASVITT TMEELEESRQ KCPPYWYKFA DKFLIWECCP LWLKIKEIVK IIVMDPFTDL
AITLCIVLNT VFMAMEYYPM DPWFTDMLYV GNLVFTAIFT AEMVLKVIAL DPYHYFQVGW
NIFDGVIVCL SLIELSLADV KGMSILRSFR LLRVFKLAKS WPTLNKLIKI IGNSVGALGN
LTLVLAIIVF IFAVVGMQLF GKYYKDCVCK ISEDCTLPRW HMNDFFHSFL IVFRVLCGEW
IETMWDCMEV AGKAPCLILY MTVMVIGNLV VLNLFLALLL SSFSADNLMS GEDDNELNNL
QIAFDRIHRA IAFIKLKFRS CCNGLCIRDK KTTEDKTFGH NGVPNHTIKD LTKNSNGEVT
GVDKSGNKYI VNSRSDDSIM SFINNPSLTV TVPIAAEESD FEMLNTEDFS SFSSNIPECH
MVVDGDDDDG QFSTSEGSTV DGLSNGEPAE LVPVVEVIKE PHDCFTAGKL SNIHLTVLLL
ITLQINNTLF FSGCIQKCKC CQVNANVGWW KVWWTLRKTC YRIVEHNWFE SFIIFMILLS
SGALAFEDIY SEQRKTIKVI LEFADKMFTF IFILEMLLKW MAYGFAKYFT NAWCWLDFLI
VDVSLVSLVA NALEYSELGP IKSLRTLRAL RPLRALSRFE GMRVVVNALM GAIPSIFNVL
LVCLIFWLIF SIMGVNLFAG KFYRCENTTT EKPFLPTEVK NETECKSYGV WKNVKVNFDN
VAMGYLALLQ VATFKGWMDI MYAAVDSQSK AGDQPEYEIN LKMYIYFVVF IIFGSFFTLN
LFIGVIIDNF NQQKRKLGGQ DIFMTDEQKK YYNAMKKLGS KKPQKPIPRP ENKLQGYVFD
FVTQQVFDIA IMVLIWLNMV TMMVEVEGQS KEWEKNLKYI NIVFIIIFSG ECLLKMIALR
QYFFINGWNI FDFIVVILSI VGIFLANVIE KYFVSPTLFR VIRLARIGRV LRLIKSAKGI
RTLLFALMMS LPALFNIGLL LFLVMFIYAI FGMSNFAYVK KEKGIDDLFN FETFGNSMIC
LFQITTSGGW DLLLAPILNT KDNSDCDSEM EHPGSNNAKG NCGNPAVGIA FFVSYIIICF
LIVVNMYIAV ILENFGVATE ESAEPLSEDD FEIFYEVWEK FDPLATQFVK YSMLSDFADS
LAPPLRIPKP NKLELISMDL PVVSGDRIHC LDILFAFTKR VLGESGEMDI LRGQMEERFM
AANPSKVSYE PITTTFRQKQ EDASAAVIQR AFRHYTRTKI FDVVRVDIEK DEQLTDKEDC
CTEKPVELTT THKTEVSGLK DSEPSSTSVT PNVNSKHEKD RSEKEVESKD ITEQDK
//
