ID A0A087YI11_POEFO Unreviewed; 638 AA.
AC A0A087YI11;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=TIR domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000017664.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000017664.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; AYCK01002553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087YI11; -.
DR STRING; 48698.ENSPFOP00000017664; -.
DR Ensembl; ENSPFOT00000017686.2; ENSPFOP00000017664.2; ENSPFOG00000017581.2.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT01090000259985; -.
DR OMA; SERCNED; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF26; INTERLEUKIN-1 RECEPTOR TYPE 1; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 309..404
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 459..624
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DISULFID 6..18
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 13..31
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 638 AA; 72941 MW; 62AE168B058853A0 CRC64;
MGRQTCGPSN FQCRTGHCIS LLWKCDGEDD CQDSSDEDPR YCKASDSSCF HMDQDKYKVI
EGEAFYYVPF DMNDPNIPDE NITWYRNVSE IKYITELVNI TKIVNITELV NITELVNITE
LVNITELVNI TKIVNITELV NITELVKITK IMKITTDETH RIYYHGGTLL FLNISADDAG
YYFARHIEPS GKCFYYHLKI EVFSETSREN LTYGAIRNSA QNINIPCPQP VKDTCKTFNG
NFTWFKGKNL IPGQHRESLW VNNATKDDED IYTCICTWTH NHKLYNSSGF RRLFVLKRAI
FRNATIVSPT SKEQLADEGS SVKLNCTVYC GINAERDCKA TWWVNGNPAK QMDGYNETST
LDIVVPSKRT FSTAILTIQR VSAKDFQKEF MCRGSGFYSG NSVTLTLKQR ESIIPFSIFR
GCVFVIVVIV AVLVKYFAID LALLFRTCFP SERCNEDMKM YDAYVVYQPQ SVDMEIENQP
FNFVTETLPS VLEDKCGYRL FIQGRDNMPG EDRVELVESC IKQSRRLMVI LTPGSGPEMM
ENPTSDQTSV IGFDWQVGLH HALLQRDMGV ILIQLGEMGP QDYAHLPPGL QHLIRQSAPI
RWPKGSRAAS KYNSPFWKRV RYLMPVRPAR KRDSSAII
//
