ID   A0A087YI63_POEFO        Unreviewed;       718 AA.
AC   A0A087YI63;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator-like 1 {ECO:0000313|Ensembl:ENSPFOP00000017716.1};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000017716.1, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000017716.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; AYCK01007463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A087YI63; -.
DR   Ensembl; ENSPFOT00000017738.2; ENSPFOP00000017716.1; ENSPFOG00000017629.2.
DR   GeneTree; ENSGT00940000156012; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF199; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT   DOMAIN          19..144
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          183..452
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          598..685
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          478..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..564
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   718 AA;  79570 MW;  E5F5E26326B9FC4F CRC64;
     AEGDRLPPGH TVSQLETCKI RSIRAGTLER LVETLLTAFG DNDLTYTSIF LSTYRAFAST
     QTVLKLLLDR YGSVEENDQE GTESSEAIRN ALASILRAWL DQCPEDFQEP PDYPCLHRLM
     EYLRKALPGS EALRRAEGLL EQLQGQANMD ETDGIGFQGN SSFCLGEDEE VEIEVQEDFL
     SFEADLVAEQ LTYMDALLFK KVVPHHCLGS IWSQRDKKDN KHSAPTIRAT ITQFNAIAAC
     VVNTVLKHRQ LRPHVRARVI QRWIDIAQEC RIRKNFSSLR AIVSALQSNP LYRLKRVWAC
     VHKDSMQTFE ELSDIFSDQN NYLTSRELLM REGTSKFASL ESCAKDHQKR THKRLQLQKE
     MGAMQGTIPY LGTFLTDLTM LDTALPDIVE GGLINFEKRR REFEVIAQIK LLQSACNSYC
     LTADPAFLRW FKNQPQLSEE ESYALSCEVE GLGDSSPTLP KPRKSMVKRI SLLFLGPDSS
     TASSPVRETP RSPPAGSSGE SMDSVSVSSN DSSGPSDNEG LASPTHNADS SQNKLSESSS
     CTSLHSMDTN SSTASGSMTP ASPSLPGRPG THRRSISLTP MCPCSASQTP AYNTQAQDAC
     IVRVSLEHGN GNLYKSILLT SQDKTPAVIA RAMAKHNLEV EPEEGFELVQ VISDEKELVI
     PDNANVFYAM NTSANFDFLL RARGSAGRPV QLRSRCSSTL PRAQHRSSLS VRLSKVTL
//